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- NCIT_C201496 IAO_0000115 "A RNA-lipoplex (RNA-LIP)-based cancer vaccine containing six messenger ribonucleic acids (mRNA) each encoding for a different tumor-associated antigen (TAA) expressed in non-small cell lung cancer (NSCLC), encapsulated in liposomes, with potential antineoplastic activity. Upon intravenous administration of the RNA-lipoplex cancer vaccine BNT116, the liposomes protect the RNA from degradation in the bloodstream, travel to the spleen and are taken up by antigen-presenting cells (APCs). The RNA is translocated to the cytoplasm and translated into the six tumor-associated proteins. The expressed proteins are processed and the human leukocyte antigen (HLA)-peptide complexes are presented to the immune system. This results in the production of various pro-inflammatory cytokines and induces antigen-specific CD8+ and CD4+ T-cell responses against the six selected TAAs." @default.
- NCIT_C201496 NCIT_NHC0 "C201496" @default.
- NCIT_C201496 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C201496 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201496 NCIT_P107 "RNA-lipoplex Cancer Vaccine BNT116" @default.
- NCIT_C201496 NCIT_P108 "RNA-lipoplex Cancer Vaccine BNT116" @default.
- NCIT_C201496 NCIT_P322 "CTRP" @default.
- NCIT_C201496 NCIT_P322 "GDC" @default.
- NCIT_C201496 normalizedInformationContent "100" @default.
- NCIT_C201496 referenceCount "1" @default.
- NCIT_C201496 hasExactSynonym "BNT 116" @default.
- NCIT_C201496 hasExactSynonym "BNT-116" @default.
- NCIT_C201496 hasExactSynonym "BNT116" @default.
- NCIT_C201496 hasExactSynonym "Cancer Vaccine BNT116" @default.
- NCIT_C201496 hasExactSynonym "FixVac Lung BNT116" @default.
- NCIT_C201496 hasExactSynonym "RNA-lipoplex Cancer Vaccine BNT116" @default.
- NCIT_C201496 hasExactSynonym "mRNA-derived NSCLC Vaccine BNT116" @default.
- NCIT_C201496 inSubset NCIT_C116977 @default.
- NCIT_C201496 inSubset NCIT_C116978 @default.
- NCIT_C201496 inSubset NCIT_C128784 @default.
- NCIT_C201496 inSubset NCIT_C157711 @default.
- NCIT_C201496 inSubset NCIT_C157712 @default.
- NCIT_C201496 inSubset NCIT_C176424 @default.
- NCIT_C201496 type Class @default.
- NCIT_C201496 isDefinedBy ncit.owl @default.
- NCIT_C201496 label "RNA-lipoplex Cancer Vaccine BNT116" @default.
- NCIT_C201496 subClassOf NCIT_C129820 @default.
- NCIT_C201496 subClassOf NCIT_C1663 @default.
- NCIT_C201496 subClassOf NCIT_C172787 @default.
- NCIT_C201496 subClassOf NCIT_C181141 @default.
- NCIT_C201496 subClassOf NCIT_C1908 @default.
- NCIT_C201496 subClassOf NCIT_C1909 @default.
- NCIT_C201496 subClassOf NCIT_C201496 @default.
- NCIT_C201496 subClassOf NCIT_C274 @default.
- NCIT_C201496 subClassOf NCIT_C307 @default.
- NCIT_C201496 subClassOf NCIT_C308 @default.
- NCIT_C201496 subClassOf NCIT_C923 @default.