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- NCIT_C201515 IAO_0000115 "An orally bioavailable, brain-penetrable inhibitor of ataxia telangiectasia mutated (ATM) kinase, with potential chemo-and radio-sensitizing and antineoplastic activities. Upon oral administration, ATM kinase inhibitor WSD-0628 selectively targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces apoptosis in damaged tumor cells, and leads to cell death in ATM-overexpressing tumor cells. WSD-0628 hypersensitizes tumors to chemo/radiotherapy. In addition, WSD-0628 is able to cross the blood-brain barrier (BBB). ATM, a serine/threonine protein kinase belonging to the phosphatidylinositol 3-kinase-related kinase (PIKK) family of protein kinases, is upregulated in a variety of cancer cell types. It is activated in response to DNA double-strand breaks (DSB) and plays a key role in DNA repair." @default.
- NCIT_C201515 NCIT_A7 NCIT_C17924 @default.
- NCIT_C201515 NCIT_NHC0 "C201515" @default.
- NCIT_C201515 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201515 NCIT_P107 "ATM Kinase Inhibitor WSD-0628" @default.
- NCIT_C201515 NCIT_P108 "ATM Kinase Inhibitor WSD-0628" @default.
- NCIT_C201515 NCIT_P322 "CTRP" @default.
- NCIT_C201515 NCIT_P322 "GDC" @default.
- NCIT_C201515 normalizedInformationContent "100" @default.
- NCIT_C201515 referenceCount "1" @default.
- NCIT_C201515 hasExactSynonym "ATM Inhibitor WSD-0628" @default.
- NCIT_C201515 hasExactSynonym "ATM Kinase Inhibitor WSD-0628" @default.
- NCIT_C201515 hasExactSynonym "WSD 0628" @default.
- NCIT_C201515 hasExactSynonym "WSD-0628" @default.
- NCIT_C201515 hasExactSynonym "WSD0628" @default.
- NCIT_C201515 inSubset NCIT_C116977 @default.
- NCIT_C201515 inSubset NCIT_C116978 @default.
- NCIT_C201515 inSubset NCIT_C128784 @default.
- NCIT_C201515 inSubset NCIT_C157711 @default.
- NCIT_C201515 inSubset NCIT_C157712 @default.
- NCIT_C201515 inSubset NCIT_C176424 @default.
- NCIT_C201515 type Class @default.
- NCIT_C201515 isDefinedBy ncit.owl @default.
- NCIT_C201515 label "ATM Kinase Inhibitor WSD-0628" @default.
- NCIT_C201515 subClassOf NCIT_C129824 @default.
- NCIT_C201515 subClassOf NCIT_C129825 @default.
- NCIT_C201515 subClassOf NCIT_C1404 @default.
- NCIT_C201515 subClassOf NCIT_C1908 @default.
- NCIT_C201515 subClassOf NCIT_C1909 @default.
- NCIT_C201515 subClassOf NCIT_C201515 @default.
- NCIT_C201515 subClassOf NCIT_C2189 @default.
- NCIT_C201515 subClassOf NCIT_C274 @default.
- NCIT_C201515 subClassOf NCIT_C471 @default.
- NCIT_C201515 subClassOf NCIT_C61074 @default.