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- NCIT_C201524 IAO_0000115 "An Fc-silenced immunoglobulin G1 (IgG1) bispecific monoclonal antibody against the tumor-associated antigen (TAA) CD30 (tumor necrosis factor receptor superfamily member 8; TNFRSF8) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD30/CD3 bispecific antibody GEN3017 targets and binds to both CD30 on the surface of tumor cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells, and induces a cytotoxic T-lymphocyte (CTL) response against CD30-expressing tumor cells. CD30, a member of the tumor necrosis factor receptor superfamily, is overexpressed on the surfaces of certain tumor cells." @default.
- NCIT_C201524 NCIT_A7 NCIT_C38906 @default.
- NCIT_C201524 NCIT_NHC0 "C201524" @default.
- NCIT_C201524 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201524 NCIT_P107 "Anti-CD30/CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 NCIT_P108 "Anti-CD30/CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 NCIT_P322 "CTRP" @default.
- NCIT_C201524 NCIT_P322 "GDC" @default.
- NCIT_C201524 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201524 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201524 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201524 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201524 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201524 normalizedInformationContent "100" @default.
- NCIT_C201524 referenceCount "1" @default.
- NCIT_C201524 hasExactSynonym "Anti-CD30/Anti-CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 hasExactSynonym "Anti-CD30/CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 hasExactSynonym "CD30 x CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 hasExactSynonym "DuoBody CD3xCD30 GEN3017" @default.
- NCIT_C201524 hasExactSynonym "DuoBody GEN3017" @default.
- NCIT_C201524 hasExactSynonym "GEN 3017" @default.
- NCIT_C201524 hasExactSynonym "GEN-3017" @default.
- NCIT_C201524 hasExactSynonym "GEN3017" @default.
- NCIT_C201524 inSubset NCIT_C116977 @default.
- NCIT_C201524 inSubset NCIT_C116978 @default.
- NCIT_C201524 inSubset NCIT_C128784 @default.
- NCIT_C201524 inSubset NCIT_C157711 @default.
- NCIT_C201524 inSubset NCIT_C157712 @default.
- NCIT_C201524 inSubset NCIT_C176424 @default.
- NCIT_C201524 type Class @default.
- NCIT_C201524 isDefinedBy ncit.owl @default.
- NCIT_C201524 label "Anti-CD30/CD3 Bispecific Antibody GEN3017" @default.
- NCIT_C201524 subClassOf NCIT_C112883 @default.
- NCIT_C201524 subClassOf NCIT_C129821 @default.
- NCIT_C201524 subClassOf NCIT_C129822 @default.
- NCIT_C201524 subClassOf NCIT_C1454 @default.
- NCIT_C201524 subClassOf NCIT_C163758 @default.
- NCIT_C201524 subClassOf NCIT_C164002 @default.
- NCIT_C201524 subClassOf NCIT_C164005 @default.
- NCIT_C201524 subClassOf NCIT_C1908 @default.
- NCIT_C201524 subClassOf NCIT_C1909 @default.
- NCIT_C201524 subClassOf NCIT_C201282 @default.
- NCIT_C201524 subClassOf NCIT_C201524 @default.
- NCIT_C201524 subClassOf NCIT_C20401 @default.
- NCIT_C201524 subClassOf NCIT_C274 @default.
- NCIT_C201524 subClassOf NCIT_C28227 @default.
- NCIT_C201524 subClassOf NCIT_C307 @default.
- NCIT_C201524 subClassOf NCIT_C308 @default.