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- NCIT_C201525 IAO_0000115 "An allosteric agonist of all isoforms of stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon administration, STING agonist CRD3874 targets and allosterically binds to STING, thereby activating the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by antigen-presenting cells (APCs), including dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system." @default.
- NCIT_C201525 NCIT_A7 NCIT_C101588 @default.
- NCIT_C201525 NCIT_NHC0 "C201525" @default.
- NCIT_C201525 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201525 NCIT_P107 "STING Agonist CRD3874" @default.
- NCIT_C201525 NCIT_P108 "STING Agonist CRD3874" @default.
- NCIT_C201525 NCIT_P322 "CTRP" @default.
- NCIT_C201525 NCIT_P322 "GDC" @default.
- NCIT_C201525 normalizedInformationContent "100" @default.
- NCIT_C201525 referenceCount "1" @default.
- NCIT_C201525 hasExactSynonym "CRD 3874" @default.
- NCIT_C201525 hasExactSynonym "CRD-3874" @default.
- NCIT_C201525 hasExactSynonym "CRD3874" @default.
- NCIT_C201525 hasExactSynonym "STING Agonist CRD3874" @default.
- NCIT_C201525 inSubset NCIT_C116977 @default.
- NCIT_C201525 inSubset NCIT_C116978 @default.
- NCIT_C201525 inSubset NCIT_C128784 @default.
- NCIT_C201525 inSubset NCIT_C157711 @default.
- NCIT_C201525 inSubset NCIT_C157712 @default.
- NCIT_C201525 inSubset NCIT_C176424 @default.
- NCIT_C201525 type Class @default.
- NCIT_C201525 isDefinedBy ncit.owl @default.
- NCIT_C201525 label "STING Agonist CRD3874" @default.
- NCIT_C201525 subClassOf NCIT_C129820 @default.
- NCIT_C201525 subClassOf NCIT_C176586 @default.
- NCIT_C201525 subClassOf NCIT_C1908 @default.
- NCIT_C201525 subClassOf NCIT_C1909 @default.
- NCIT_C201525 subClassOf NCIT_C201525 @default.
- NCIT_C201525 subClassOf NCIT_C274 @default.
- NCIT_C201525 subClassOf NCIT_C308 @default.