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- NCIT_C201546 IAO_0000115 "The monohydrate dihydrochloride salt form of momelotinib, an orally bioavailable small molecule inhibitor of wild-type (WT) Janus kinases 1 and 2 (JAK1/2), the JAK2 mutant form JAK2V617F, and activin A receptor type 1 (ACVR1; activin receptor like kinase 2; ALK2), with antineoplastic activity. Upon oral administration, momelotinib competes with JAK1/2 for ATP binding, which results in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and leads to the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells. In addition, the inhibition of ALK2 prevents liver hepcidin formation, increases iron availability and increases red blood cell (RBC) production. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types." @default.
- NCIT_C201546 NCIT_A6 NCIT_C88311 @default.
- NCIT_C201546 NCIT_NHC0 "C201546" @default.
- NCIT_C201546 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201546 NCIT_P108 "Momelotinib Dihydrochloride Monohydrate" @default.
- NCIT_C201546 NCIT_P210 "1841094-17-4" @default.
- NCIT_C201546 NCIT_P319 "LDX8893L5D" @default.
- NCIT_C201546 NCIT_P322 "FDA" @default.
- NCIT_C201546 NCIT_P399 "660135" @default.
- NCIT_C201546 normalizedInformationContent "100" @default.
- NCIT_C201546 referenceCount "1" @default.
- NCIT_C201546 hasExactSynonym "CYT387 Dihydrochloride Monohydrate" @default.
- NCIT_C201546 hasExactSynonym "MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE" @default.
- NCIT_C201546 hasExactSynonym "Momelotinib Dihydrochloride Monohydrate" @default.
- NCIT_C201546 hasExactSynonym "N-(Cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4- yl)benzamide Dihydrochloride Monohydrate" @default.
- NCIT_C201546 hasExactSynonym "Ojjaara" @default.
- NCIT_C201546 inSubset NCIT_C128784 @default.
- NCIT_C201546 inSubset NCIT_C176424 @default.
- NCIT_C201546 inSubset NCIT_C63923 @default.
- NCIT_C201546 type Class @default.
- NCIT_C201546 isDefinedBy ncit.owl @default.
- NCIT_C201546 label "Momelotinib Dihydrochloride Monohydrate" @default.
- NCIT_C201546 subClassOf NCIT_C129824 @default.
- NCIT_C201546 subClassOf NCIT_C129825 @default.
- NCIT_C201546 subClassOf NCIT_C1404 @default.
- NCIT_C201546 subClassOf NCIT_C141136 @default.
- NCIT_C201546 subClassOf NCIT_C163758 @default.
- NCIT_C201546 subClassOf NCIT_C172200 @default.
- NCIT_C201546 subClassOf NCIT_C1908 @default.
- NCIT_C201546 subClassOf NCIT_C1909 @default.
- NCIT_C201546 subClassOf NCIT_C1967 @default.
- NCIT_C201546 subClassOf NCIT_C201546 @default.
- NCIT_C201546 subClassOf NCIT_C2189 @default.
- NCIT_C201546 subClassOf NCIT_C274 @default.
- NCIT_C201546 subClassOf NCIT_C471 @default.