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- NCIT_C20223 IAO_0000115 "HGH Genes (Somatotropin/Prolactin Family) share a high degree of sequence identity and encode alternatively spliced diverse isoforms of Growth Hormone, a small secreted peptide hormone that affects gene expression, metabolism, and growth control. Due to alternative splicing, differential posttranslational modifications, optional binding to GHBP or alpha2-macroglobulin, and potential proteolytic processing, circulating GH shows great heterogeneity as a disulfide-linked or non-covalently associated monomer, dimer, trimer, tetramer, or pentamer in homopolymeric and heteropolymeric combinations. GH stimulates the liver and other tissues to secrete IGF-1. GH stimulates amino acid uptake and protein synthesis in muscle and other tissues and stimulates differentiation and proliferation of myoblasts. GH also stimulates mitosis, cell growth, and differentiation of other cell types. (NCI)" @default.
- NCIT_C20223 NCIT_NHC0 "C20223" @default.
- NCIT_C20223 NCIT_P106 "Gene or Genome" @default.
- NCIT_C20223 NCIT_P108 "hGH Gene" @default.
- NCIT_C20223 NCIT_P207 "C1337049" @default.
- NCIT_C20223 NCIT_P366 "hGH_Gene" @default.
- NCIT_C20223 NCIT_R37 NCIT_C16395 @default.
- NCIT_C20223 NCIT_R37 NCIT_C17828 @default.
- NCIT_C20223 NCIT_R37 NCIT_C21124 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14182 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14225 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14234 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14250 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14262 @default.
- NCIT_C20223 NCIT_R41 NCIT_C14282 @default.
- NCIT_C20223 NCIT_R41 NCIT_C25796 @default.
- NCIT_C20223 NCIT_R41 NCIT_C79740 @default.
- NCIT_C20223 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C20223 referenceCount "6" @default.
- NCIT_C20223 hasExactSynonym "Human Growth Hormone Gene" @default.
- NCIT_C20223 hasExactSynonym "hGH Gene" @default.
- NCIT_C20223 type Class @default.
- NCIT_C20223 isDefinedBy ncit.owl @default.
- NCIT_C20223 label "hGH Gene" @default.
- NCIT_C20223 subClassOf NCIT_C16612 @default.
- NCIT_C20223 subClassOf NCIT_C20223 @default.
- NCIT_C20223 subClassOf NCIT_C25994 @default.