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- NCIT_C20230 IAO_0000115 "HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin." @default.
- NCIT_C20230 NCIT_NHC0 "C20230" @default.
- NCIT_C20230 NCIT_P106 "Cell" @default.
- NCIT_C20230 NCIT_P108 "HL-60/MX1" @default.
- NCIT_C20230 NCIT_P207 "C1512308" @default.
- NCIT_C20230 NCIT_P366 "HL-60_MX1" @default.
- NCIT_C20230 normalizedInformationContent "100" @default.
- NCIT_C20230 referenceCount "1" @default.
- NCIT_C20230 hasExactSynonym "HL-60/MX1" @default.
- NCIT_C20230 type Class @default.
- NCIT_C20230 isDefinedBy ncit.owl @default.
- NCIT_C20230 label "HL-60/MX1" @default.
- NCIT_C20230 subClassOf NCIT_C139309 @default.
- NCIT_C20230 subClassOf NCIT_C16403 @default.
- NCIT_C20230 subClassOf NCIT_C19157 @default.
- NCIT_C20230 subClassOf NCIT_C192998 @default.
- NCIT_C20230 subClassOf NCIT_C20181 @default.
- NCIT_C20230 subClassOf NCIT_C20218 @default.
- NCIT_C20230 subClassOf NCIT_C20230 @default.
- NCIT_C20230 subClassOf NCIT_C20313 @default.
- NCIT_C20230 subClassOf NCIT_C48187 @default.
- NCIT_C20230 subClassOf NCIT_C70699 @default.