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- NCIT_C203 IAO_0000115 "A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death." @default.
- NCIT_C203 NCIT_A32 NCIT_C1909 @default.
- NCIT_C203 NCIT_NHC0 "C203" @default.
- NCIT_C203 NCIT_P106 "Organic Chemical" @default.
- NCIT_C203 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C203 NCIT_P108 "Acridine" @default.
- NCIT_C203 NCIT_P207 "C0001186" @default.
- NCIT_C203 NCIT_P210 "260-94-6" @default.
- NCIT_C203 NCIT_P319 "42NI1P5Q1X" @default.
- NCIT_C203 NCIT_P322 "FDA" @default.
- NCIT_C203 NCIT_P322 "GDC" @default.
- NCIT_C203 NCIT_P366 "Acridine" @default.
- NCIT_C203 NCIT_P368 "CHEBI:36420" @default.
- NCIT_C203 NCIT_P375 "Acridine" @default.
- NCIT_C203 normalizedInformationContent "100" @default.
- NCIT_C203 referenceCount "1" @default.
- NCIT_C203 hasExactSynonym "ACRIDINE" @default.
- NCIT_C203 hasExactSynonym "Acridine" @default.
- NCIT_C203 inSubset NCIT_C128784 @default.
- NCIT_C203 inSubset NCIT_C157711 @default.
- NCIT_C203 inSubset NCIT_C157712 @default.
- NCIT_C203 inSubset NCIT_C177537 @default.
- NCIT_C203 inSubset NCIT_C63923 @default.
- NCIT_C203 type Class @default.
- NCIT_C203 isDefinedBy ncit.owl @default.
- NCIT_C203 label "Acridine" @default.
- NCIT_C203 subClassOf NCIT_C186664 @default.
- NCIT_C203 subClassOf NCIT_C1908 @default.
- NCIT_C203 subClassOf NCIT_C1909 @default.
- NCIT_C203 subClassOf NCIT_C203 @default.
- NCIT_C203 subClassOf NCIT_C274 @default.
- NCIT_C203 subClassOf NCIT_C2842 @default.
- NCIT_C203 subClassOf NCIT_C582 @default.