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- NCIT_C20322 IAO_0000115 "High mobility group protein HMG-I (107 aa, ~12 kDa) is encoded by the human HMGA1 gene. This protein plays a role in the regulation of both transcription and chromatin structure." @default.
- NCIT_C20322 NCIT_NHC0 "C20322" @default.
- NCIT_C20322 NCIT_P100 "600701" @default.
- NCIT_C20322 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20322 NCIT_P108 "High Mobility Group Protein HMG-I" @default.
- NCIT_C20322 NCIT_P208 "CL414496" @default.
- NCIT_C20322 NCIT_P325 "A protein that binds to the DNA and certain proteins in chromosomes. It is involved in many functions in the cell, and helps protect cells from dying. HMGA1 is found at high levels in several types of cancer cells." @default.
- NCIT_C20322 NCIT_P366 "HMGA1a" @default.
- NCIT_C20322 NCIT_P93 "P17096" @default.
- NCIT_C20322 NCIT_P98 "HMGA1a is one of three protein products of the same gene, HMGA1, generated by alternative splicing. The HMGA1a protein contains three basic domains, named AT-hooks and an acidic C-terminal region. AT-hooks are responsible for binding to AT-rich sequences inside the minor groove of DNA. Phosphorylation of HMGA1a by both PKC and cdc-2 kinases strongly reduces its DNA binding affinity and is critical in cell cycle progression. HMGA1a activates the interferon-beta gene (IFN-beta) by functioning as the essential architectural component for the assembly and stability of the IFN-beta enhanceosome. (PMID11576996)" @default.
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- NCIT_C20322 normalizedInformationContent "100" @default.
- NCIT_C20322 referenceCount "1" @default.
- NCIT_C20322 hasExactSynonym "HMG I" @default.
- NCIT_C20322 hasExactSynonym "HMG-I" @default.
- NCIT_C20322 hasExactSynonym "HMG-I/Y" @default.
- NCIT_C20322 hasExactSynonym "HMGA1" @default.
- NCIT_C20322 hasExactSynonym "HMGA1a" @default.
- NCIT_C20322 hasExactSynonym "HMGI" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group AT-Hook 1a" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group AT-Hook Protein 1" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group AT-Hook Protein 1a" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group Protein A1" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group Protein A1a" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group Protein HMG Isoform HMG-I" @default.
- NCIT_C20322 hasExactSynonym "High Mobility Group Protein HMG-I" @default.
- NCIT_C20322 type Class @default.
- NCIT_C20322 isDefinedBy ncit.owl @default.
- NCIT_C20322 label "High Mobility Group Protein HMG-I" @default.
- NCIT_C20322 subClassOf NCIT_C17021 @default.
- NCIT_C20322 subClassOf NCIT_C178295 @default.
- NCIT_C20322 subClassOf NCIT_C18466 @default.
- NCIT_C20322 subClassOf NCIT_C20027 @default.
- NCIT_C20322 subClassOf NCIT_C20322 @default.
- NCIT_C20322 subClassOf NCIT_C26199 @default.
- NCIT_C20322 subClassOf NCIT_C26548 @default.
- NCIT_C20322 equivalentClass B125a70372bd2b5285ce743e7ca009931 @default.
- NCIT_C20322 equivalentClass B4939826d945e16ce7ea17b18114af7d7 @default.