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- NCIT_C20325 IAO_0000115 "Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81)" @default.
- NCIT_C20325 NCIT_NHC0 "C20325" @default.
- NCIT_C20325 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20325 NCIT_P108 "HMGA Family Protein" @default.
- NCIT_C20325 NCIT_P207 "C0905617" @default.
- NCIT_C20325 NCIT_P366 "HMGA_Family_Protein" @default.
- NCIT_C20325 NCIT_R50 NCIT_C12219 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13303 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13379 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13422 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13425 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13671 @default.
- NCIT_C20325 NCIT_R50 NCIT_C13741 @default.
- NCIT_C20325 NCIT_R50 NCIT_C14134 @default.
- NCIT_C20325 NCIT_R50 NCIT_C21599 @default.
- NCIT_C20325 NCIT_R52 NCIT_C16518 @default.
- NCIT_C20325 NCIT_R52 NCIT_C17021 @default.
- NCIT_C20325 NCIT_R52 NCIT_C17728 @default.
- NCIT_C20325 NCIT_R52 NCIT_C18466 @default.
- NCIT_C20325 NCIT_R52 NCIT_C20027 @default.
- NCIT_C20325 NCIT_R52 NCIT_C26199 @default.
- NCIT_C20325 NCIT_R52 NCIT_C26548 @default.
- NCIT_C20325 NCIT_R53 NCIT_C17208 @default.
- NCIT_C20325 NCIT_R53 NCIT_C17710 @default.
- NCIT_C20325 NCIT_R53 NCIT_C17828 @default.
- NCIT_C20325 NCIT_R53 NCIT_C18219 @default.
- NCIT_C20325 NCIT_R53 NCIT_C18597 @default.
- NCIT_C20325 NCIT_R53 NCIT_C19077 @default.
- NCIT_C20325 NCIT_R53 NCIT_C19797 @default.
- NCIT_C20325 NCIT_R53 NCIT_C19986 @default.
- NCIT_C20325 NCIT_R53 NCIT_C21049 @default.
- NCIT_C20325 NCIT_R53 NCIT_C21050 @default.
- NCIT_C20325 NCIT_R53 NCIT_C28498 @default.
- NCIT_C20325 NCIT_R53 NCIT_C28614 @default.
- NCIT_C20325 NCIT_R53 NCIT_C29836 @default.
- NCIT_C20325 NCIT_R53 NCIT_C40523 @default.
- NCIT_C20325 NCIT_R53 NCIT_C40800 @default.
- NCIT_C20325 NCIT_R53 NCIT_C41543 @default.
- NCIT_C20325 NCIT_R54 NCIT_C16612 @default.
- NCIT_C20325 NCIT_R54 NCIT_C20570 @default.
- NCIT_C20325 NCIT_R54 NCIT_C20573 @default.
- NCIT_C20325 NCIT_R54 NCIT_C54362 @default.
- NCIT_C20325 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C20325 referenceCount "5" @default.
- NCIT_C20325 hasExactSynonym "AT-Hook Protein" @default.
- NCIT_C20325 hasExactSynonym "HMG-I(Y) Protein" @default.
- NCIT_C20325 hasExactSynonym "HMG-I/Y Protein" @default.
- NCIT_C20325 hasExactSynonym "HMG-I/Y/C" @default.
- NCIT_C20325 hasExactSynonym "HMGA Family Protein" @default.
- NCIT_C20325 hasExactSynonym "HMGI(Y) Protein" @default.
- NCIT_C20325 hasExactSynonym "High Mobility Group A Protein" @default.
- NCIT_C20325 type Class @default.
- NCIT_C20325 isDefinedBy ncit.owl @default.
- NCIT_C20325 label "HMGA Family Protein" @default.
- NCIT_C20325 subClassOf NCIT_C16677 @default.
- NCIT_C20325 subClassOf NCIT_C17021 @default.
- NCIT_C20325 subClassOf NCIT_C20130 @default.
- NCIT_C20325 subClassOf NCIT_C20325 @default.
- NCIT_C20325 subClassOf NCIT_C26548 @default.
- NCIT_C20325 equivalentClass B5ed9ea04a0d4ce93b50a0ab36ed3d12a @default.
- NCIT_C20325 equivalentClass Bb811c77354f8f5454da7df26b3a3b3d4 @default.