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- NCIT_C20326 IAO_0000115 "The HMG-Box Family proteins are relatively abundant vertebrate DNA-binding and bending proteins that bind with structure specificity, rather than sequence specificity, and plays an architectural role in the assembly of nucleoprotein complexes. They have two homologous HMG-box DNA-binding domains connected by a short basic linker to an acidic carboxy-terminal tail that differs in length. The length (and possibly sequence) of the acidic tail may be the dominant factor in mediating the differences in properties among themselves and finely tunes the DNA-binding properties of the tandem HMG boxes, to fulfill different cellular roles. The tail is essential for structure-selective DNA-binding of the HMG boxes to DNA minicircles in the presence of equimolar linear DNA, and has little effect on the affinity for this already highly distorted DNA ligand, in contrast to binding to linear and four-way junction DNA. (J Mol Biol 2000 304:135-49)" @default.
- NCIT_C20326 NCIT_NHC0 "C20326" @default.
- NCIT_C20326 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20326 NCIT_P108 "HMGB Family Protein" @default.
- NCIT_C20326 NCIT_P207 "C0949597" @default.
- NCIT_C20326 NCIT_P366 "HMGB_Family_Protein" @default.
- NCIT_C20326 NCIT_R50 NCIT_C12219 @default.
- NCIT_C20326 NCIT_R50 NCIT_C13303 @default.
- NCIT_C20326 NCIT_R50 NCIT_C13379 @default.
- NCIT_C20326 NCIT_R50 NCIT_C13425 @default.
- NCIT_C20326 NCIT_R50 NCIT_C13671 @default.
- NCIT_C20326 NCIT_R50 NCIT_C14134 @default.
- NCIT_C20326 NCIT_R50 NCIT_C21599 @default.
- NCIT_C20326 NCIT_R52 NCIT_C16518 @default.
- NCIT_C20326 NCIT_R52 NCIT_C17021 @default.
- NCIT_C20326 NCIT_R52 NCIT_C17728 @default.
- NCIT_C20326 NCIT_R52 NCIT_C18466 @default.
- NCIT_C20326 NCIT_R52 NCIT_C20027 @default.
- NCIT_C20326 NCIT_R52 NCIT_C26199 @default.
- NCIT_C20326 NCIT_R52 NCIT_C26548 @default.
- NCIT_C20326 NCIT_R53 NCIT_C17208 @default.
- NCIT_C20326 NCIT_R53 NCIT_C17710 @default.
- NCIT_C20326 NCIT_R53 NCIT_C17828 @default.
- NCIT_C20326 NCIT_R53 NCIT_C18219 @default.
- NCIT_C20326 NCIT_R53 NCIT_C18597 @default.
- NCIT_C20326 NCIT_R53 NCIT_C19077 @default.
- NCIT_C20326 NCIT_R53 NCIT_C19797 @default.
- NCIT_C20326 NCIT_R53 NCIT_C19986 @default.
- NCIT_C20326 NCIT_R53 NCIT_C21049 @default.
- NCIT_C20326 NCIT_R53 NCIT_C21050 @default.
- NCIT_C20326 NCIT_R53 NCIT_C28498 @default.
- NCIT_C20326 NCIT_R53 NCIT_C28614 @default.
- NCIT_C20326 NCIT_R53 NCIT_C29836 @default.
- NCIT_C20326 NCIT_R53 NCIT_C40523 @default.
- NCIT_C20326 NCIT_R53 NCIT_C40800 @default.
- NCIT_C20326 NCIT_R53 NCIT_C41543 @default.
- NCIT_C20326 NCIT_R54 NCIT_C16612 @default.
- NCIT_C20326 NCIT_R54 NCIT_C20570 @default.
- NCIT_C20326 NCIT_R54 NCIT_C20574 @default.
- NCIT_C20326 NCIT_R54 NCIT_C54362 @default.
- NCIT_C20326 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C20326 referenceCount "4" @default.
- NCIT_C20326 hasExactSynonym "HMG-1/-2" @default.
- NCIT_C20326 hasExactSynonym "HMG-Box Protein" @default.
- NCIT_C20326 hasExactSynonym "HMGB Family Protein" @default.
- NCIT_C20326 hasExactSynonym "High Mobility Group B Protein" @default.
- NCIT_C20326 type Class @default.
- NCIT_C20326 isDefinedBy ncit.owl @default.
- NCIT_C20326 label "HMGB Family Protein" @default.
- NCIT_C20326 subClassOf NCIT_C16677 @default.
- NCIT_C20326 subClassOf NCIT_C17021 @default.
- NCIT_C20326 subClassOf NCIT_C20130 @default.
- NCIT_C20326 subClassOf NCIT_C20326 @default.
- NCIT_C20326 subClassOf NCIT_C26548 @default.
- NCIT_C20326 equivalentClass B2aa041b12c6218a70c354ef418105fef @default.
- NCIT_C20326 equivalentClass Bd6dda3dc5d619d78f38571f50cfcf017 @default.