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- NCIT_C2045 IAO_0000115 "An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity. MMI270 inhibits a broad spectrum of matrix metalloproteinases (MMPs) (specifically MMP-1, 2, 3, 9, and 13), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also downregulate lymphangiogenesis, resulting in decreased lymphatic system-related metastasis. (NCI04)" @default.
- NCIT_C2045 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2045 NCIT_NHC0 "C2045" @default.
- NCIT_C2045 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2045 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2045 NCIT_P108 "Matrix Metalloproteinase Inhibitor MMI270" @default.
- NCIT_C2045 NCIT_P207 "C0385829" @default.
- NCIT_C2045 NCIT_P322 "GDC" @default.
- NCIT_C2045 NCIT_P366 "MMI270" @default.
- NCIT_C2045 NCIT_P375 "Matrix Metalloproteinase Inhibitor MMI270" @default.
- NCIT_C2045 normalizedInformationContent "100" @default.
- NCIT_C2045 referenceCount "1" @default.
- NCIT_C2045 hasExactSynonym "(2R)-N-Hydroxy-2-[[(4-methoxyphenyl)sulfonyl](3-pyridinylmethyl)amino]-3-methylbutanamide Monohydrochloride" @default.
- NCIT_C2045 hasExactSynonym "CGS27023" @default.
- NCIT_C2045 hasExactSynonym "CGS27023A" @default.
- NCIT_C2045 hasExactSynonym "MMI 270B CGS27023A" @default.
- NCIT_C2045 hasExactSynonym "Matrix Metalloproteinase Inhibitor MMI270" @default.
- NCIT_C2045 hasExactSynonym "N-hydroxy-2(R)-[(4-methoxysulfony) (3-picolyl)-amino]-3-metylbutaneamide hydrochloride monohydrate" @default.
- NCIT_C2045 hasExactSynonym "N-hydroxy-2(R)-[[4- methoxysulfonyl](3-picolyl)amino]-3-methylbutaneamide hydrochloride" @default.
- NCIT_C2045 inSubset NCIT_C128784 @default.
- NCIT_C2045 inSubset NCIT_C157711 @default.
- NCIT_C2045 inSubset NCIT_C157712 @default.
- NCIT_C2045 inSubset NCIT_C177537 @default.
- NCIT_C2045 type Class @default.
- NCIT_C2045 isDefinedBy ncit.owl @default.
- NCIT_C2045 label "Matrix Metalloproteinase Inhibitor MMI270" @default.
- NCIT_C2045 subClassOf NCIT_C1742 @default.
- NCIT_C2045 subClassOf NCIT_C1908 @default.
- NCIT_C2045 subClassOf NCIT_C1909 @default.
- NCIT_C2045 subClassOf NCIT_C1970 @default.
- NCIT_C2045 subClassOf NCIT_C2045 @default.
- NCIT_C2045 subClassOf NCIT_C274 @default.
- NCIT_C2045 subClassOf NCIT_C471 @default.
- NCIT_C2045 subClassOf NCIT_C783 @default.