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- NCIT_C20450 IAO_0000115 "Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis." @default.
- NCIT_C20450 NCIT_NHC0 "C20450" @default.
- NCIT_C20450 NCIT_P100 "192240" @default.
- NCIT_C20450 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20450 NCIT_P107 "Vascular Endothelial Growth Factor A" @default.
- NCIT_C20450 NCIT_P108 "Vascular Endothelial Growth Factor A" @default.
- NCIT_C20450 NCIT_P207 "C1171892" @default.
- NCIT_C20450 NCIT_P322 "CTRP" @default.
- NCIT_C20450 NCIT_P325 "A substance made by cells that stimulates new blood vessel formation." @default.
- NCIT_C20450 NCIT_P366 "Vascular_Endothelial_Growth_Factor" @default.
- NCIT_C20450 NCIT_P93 "P15692" @default.
- NCIT_C20450 NCIT_P98 "Encoded by human VEGF Gene (PDGF/VEGF Family), widely expressed 232-amino acid 27 kD (precursor) VEGF exhibits seven isoforms: VEGF206, -189, -183, -165/VEGF, -148, -145, and -121. VEGF121 is acidic; VEGF165 is more basic and binds heparin/ECM; VEGF189 is very basic. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein angiogenic growth factor; it may heterodimerize with PLGF. VEGF inhibits apoptosis and promotes endothelial proliferation, cell migration, and vascular permeabilization. VEGF interacts with VEGFR1/FLT-1 and VEGFR2/KDR/FLK1 receptors. VEGF145 may inhibit -165 binding to FLK1. Collapsin/semaphorin receptor Neuropilin-1 (VEGF165R) mediates neuronal cell guidance and binds VEGF165 and -145, but not -121; it enhances VEGF165/KDR binding and chemotaxis. (OMIM, Swiss-Prot, LocusLink, and NCI)" @default.
- NCIT_C20450 NCIT_P98 "The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon. (UniProt)" @default.
- NCIT_C20450 NCIT_P98 "Vascular endothelial growth factor A has multiple protein isoforms that range from ~15 kDa to ~27 kDa and are the result of alternative splicing. The isoforms are denoted by the term VEGF followed by the number of amino acids contained therein. This entry uses VEGF206 to represent the canonical vascular endothelial growth factor A." @default.
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- NCIT_C20450 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C20450 referenceCount "3" @default.
- NCIT_C20450 hasExactSynonym "VEGF" @default.
- NCIT_C20450 hasExactSynonym "VEGF-A" @default.
- NCIT_C20450 hasExactSynonym "VEGF121" @default.
- NCIT_C20450 hasExactSynonym "VEGF145" @default.
- NCIT_C20450 hasExactSynonym "VEGF148" @default.
- NCIT_C20450 hasExactSynonym "VEGF165" @default.
- NCIT_C20450 hasExactSynonym "VEGF183" @default.
- NCIT_C20450 hasExactSynonym "VEGF189" @default.
- NCIT_C20450 hasExactSynonym "VEGF206" @default.
- NCIT_C20450 hasExactSynonym "VPF" @default.
- NCIT_C20450 hasExactSynonym "Vascular Endothelial Growth Factor A" @default.
- NCIT_C20450 hasExactSynonym "Vascular Endothelial Growth Factor" @default.
- NCIT_C20450 hasExactSynonym "Vascular Permeability Factor" @default.
- NCIT_C20450 inSubset NCIT_C116977 @default.
- NCIT_C20450 inSubset NCIT_C142799 @default.
- NCIT_C20450 inSubset NCIT_C142800 @default.
- NCIT_C20450 type Class @default.
- NCIT_C20450 isDefinedBy ncit.owl @default.
- NCIT_C20450 label "Vascular Endothelial Growth Factor A" @default.
- NCIT_C20450 subClassOf NCIT_C126412 @default.
- NCIT_C20450 subClassOf NCIT_C17021 @default.
- NCIT_C20450 subClassOf NCIT_C20027 @default.
- NCIT_C20450 subClassOf NCIT_C20424 @default.
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- NCIT_C20450 subClassOf NCIT_C26548 @default.
- NCIT_C20450 equivalentClass Bab0698fce93d37fda59bf49af7cca219 @default.
- NCIT_C20450 equivalentClass Bf4a55c9a797c200ab5a7b001ccf62598 @default.