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- NCIT_C2047 IAO_0000115 "A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin. Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization. This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI04)" @default.
- NCIT_C2047 NCIT_NHC0 "C2047" @default.
- NCIT_C2047 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2047 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2047 NCIT_P108 "Prolactin 16-kD Fragment" @default.
- NCIT_C2047 NCIT_P207 "C1514483" @default.
- NCIT_C2047 NCIT_P366 "Prolactin_16-kD_Fragment" @default.
- NCIT_C2047 normalizedInformationContent "100" @default.
- NCIT_C2047 referenceCount "1" @default.
- NCIT_C2047 hasExactSynonym "16K PRL" @default.
- NCIT_C2047 hasExactSynonym "Prolactin 16-kD Fragment" @default.
- NCIT_C2047 type Class @default.
- NCIT_C2047 isDefinedBy ncit.owl @default.
- NCIT_C2047 label "Prolactin 16-kD Fragment" @default.
- NCIT_C2047 subClassOf NCIT_C1742 @default.
- NCIT_C2047 subClassOf NCIT_C1908 @default.
- NCIT_C2047 subClassOf NCIT_C1909 @default.
- NCIT_C2047 subClassOf NCIT_C2047 @default.
- NCIT_C2047 subClassOf NCIT_C2143 @default.
- NCIT_C2047 subClassOf NCIT_C274 @default.