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- NCIT_C2051 IAO_0000115 "A highly cytotoxic macrocyclic lactone polyether with antitumor activity. Spongistatin, originally isolated from marine Spongia species, binds to the vinca domain of tubulin, thereby interferes with microtubule assembly and results in inhibition of mitosis. This agent does not affect the binding of colchicine to tubulin, but it was a potent inhibitor of the binding of vinblastine and GTP to tubulin." @default.
- NCIT_C2051 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2051 NCIT_NHC0 "C2051" @default.
- NCIT_C2051 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2051 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2051 NCIT_P108 "Spongistatin" @default.
- NCIT_C2051 NCIT_P171 "8232226" @default.
- NCIT_C2051 NCIT_P207 "C0248118" @default.
- NCIT_C2051 NCIT_P210 "148179-94-6" @default.
- NCIT_C2051 NCIT_P322 "GDC" @default.
- NCIT_C2051 NCIT_P366 "Spongistatin" @default.
- NCIT_C2051 NCIT_P375 "Spongistatin" @default.
- NCIT_C2051 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2051 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2051 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2051 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2051 normalizedInformationContent "100" @default.
- NCIT_C2051 referenceCount "1" @default.
- NCIT_C2051 hasExactSynonym "Altohyrtin A" @default.
- NCIT_C2051 hasExactSynonym "Spongistatin 1" @default.
- NCIT_C2051 hasExactSynonym "Spongistatin" @default.
- NCIT_C2051 inSubset NCIT_C128784 @default.
- NCIT_C2051 inSubset NCIT_C157711 @default.
- NCIT_C2051 inSubset NCIT_C157712 @default.
- NCIT_C2051 inSubset NCIT_C177537 @default.
- NCIT_C2051 type Class @default.
- NCIT_C2051 isDefinedBy ncit.owl @default.
- NCIT_C2051 label "Spongistatin" @default.
- NCIT_C2051 subClassOf NCIT_C186664 @default.
- NCIT_C2051 subClassOf NCIT_C1908 @default.
- NCIT_C2051 subClassOf NCIT_C1909 @default.
- NCIT_C2051 subClassOf NCIT_C2051 @default.
- NCIT_C2051 subClassOf NCIT_C25974 @default.
- NCIT_C2051 subClassOf NCIT_C273 @default.
- NCIT_C2051 subClassOf NCIT_C274 @default.
- NCIT_C2051 subClassOf NCIT_C67422 @default.