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- NCIT_C20514 IAO_0000115 "Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)" @default.
- NCIT_C20514 NCIT_NHC0 "C20514" @default.
- NCIT_C20514 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20514 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C20514 NCIT_P107 "Interleukin-12" @default.
- NCIT_C20514 NCIT_P108 "Interleukin-12" @default.
- NCIT_C20514 NCIT_P207 "C0123759" @default.
- NCIT_C20514 NCIT_P322 "CTRP" @default.
- NCIT_C20514 NCIT_P366 "Interleukin-12" @default.
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- NCIT_C20514 NCIT_R53 NCIT_C19053 @default.
- NCIT_C20514 NCIT_R53 NCIT_C19940 @default.
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- NCIT_C20514 NCIT_R53 NCIT_C26280 @default.
- NCIT_C20514 NCIT_R53 NCIT_C40833 @default.
- NCIT_C20514 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C20514 referenceCount "3" @default.
- NCIT_C20514 hasExactSynonym "CLMF" @default.
- NCIT_C20514 hasExactSynonym "Cytotoxic Lymphocyte Maturation Factor" @default.
- NCIT_C20514 hasExactSynonym "IL-12 p70" @default.
- NCIT_C20514 hasExactSynonym "IL-12" @default.
- NCIT_C20514 hasExactSynonym "IL-12p70" @default.
- NCIT_C20514 hasExactSynonym "IL12" @default.
- NCIT_C20514 hasExactSynonym "Interleukin 12" @default.
- NCIT_C20514 hasExactSynonym "Interleukin-12" @default.
- NCIT_C20514 hasExactSynonym "NKSF" @default.
- NCIT_C20514 hasExactSynonym "Natural Killer Cell Stimulatory Factor" @default.
- NCIT_C20514 inSubset NCIT_C116977 @default.
- NCIT_C20514 inSubset NCIT_C142799 @default.
- NCIT_C20514 inSubset NCIT_C142800 @default.
- NCIT_C20514 type Class @default.
- NCIT_C20514 isDefinedBy ncit.owl @default.
- NCIT_C20514 label "Interleukin-12" @default.
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