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- NCIT_C2052 IAO_0000115 "The cephalostatins comprise a family of more than 30 trisdecacyclic bissteroidal pyrazines with extreme cytotoxicity against human tumors, isolated from the African marine worm Cephalodiscus gilchristi. The mechanism of action of these compounds remains unknown. Beside a steroidal platform, critical features implicated in the pharmacophore include a set of covalently linked polar and nonpolar domains and the spiroketals. It was shown that cephalostatin 1 induces a novel pathway of receptor-independent apoptosis that selectively uses Smac/DIABLO (second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with a low isoelectric point) as a mitochondrial signaling molecule. Apoptosis was found to be dependent on caspase activity because the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone blocks cephalostatin 1-mediated DNA fragmentation. (NCI)" @default.
- NCIT_C2052 NCIT_NHC0 "C2052" @default.
- NCIT_C2052 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2052 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2052 NCIT_P108 "Cephalostatin" @default.
- NCIT_C2052 NCIT_P207 "C1516395" @default.
- NCIT_C2052 NCIT_P366 "Cephalostatin" @default.
- NCIT_C2052 normalizedInformationContent "100" @default.
- NCIT_C2052 referenceCount "1" @default.
- NCIT_C2052 hasExactSynonym "Cephalostatin" @default.
- NCIT_C2052 type Class @default.
- NCIT_C2052 isDefinedBy ncit.owl @default.
- NCIT_C2052 label "Cephalostatin" @default.
- NCIT_C2052 subClassOf NCIT_C129839 @default.
- NCIT_C2052 subClassOf NCIT_C1908 @default.
- NCIT_C2052 subClassOf NCIT_C1909 @default.
- NCIT_C2052 subClassOf NCIT_C2052 @default.
- NCIT_C2052 subClassOf NCIT_C274 @default.