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- NCIT_C20599 IAO_0000115 "The assembly of transcription complexes at eukaryotic promoters involves a number of distinct steps, including chromatin remodeling and recruitment of a TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these stages is controlled by positive and negative factors that regulate the interactions of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might depend in part on competition between TBP inhibitors and the holoenzyme for access to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators. (from PMID 10974559)" @default.
- NCIT_C20599 NCIT_NHC0 "C20599" @default.
- NCIT_C20599 NCIT_P106 "Gene or Genome" @default.
- NCIT_C20599 NCIT_P108 "TBP Inhibitor Gene" @default.
- NCIT_C20599 NCIT_P207 "C1336595" @default.
- NCIT_C20599 NCIT_P366 "TBP_Inhibitor_Gene" @default.
- NCIT_C20599 NCIT_R37 NCIT_C17710 @default.
- NCIT_C20599 NCIT_R37 NCIT_C17828 @default.
- NCIT_C20599 NCIT_R37 NCIT_C18219 @default.
- NCIT_C20599 NCIT_R37 NCIT_C18597 @default.
- NCIT_C20599 NCIT_R37 NCIT_C19077 @default.
- NCIT_C20599 NCIT_R37 NCIT_C19986 @default.
- NCIT_C20599 NCIT_R37 NCIT_C21049 @default.
- NCIT_C20599 NCIT_R37 NCIT_C21050 @default.
- NCIT_C20599 NCIT_R37 NCIT_C28498 @default.
- NCIT_C20599 NCIT_R37 NCIT_C40523 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14182 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14225 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14234 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14250 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14262 @default.
- NCIT_C20599 NCIT_R41 NCIT_C14282 @default.
- NCIT_C20599 NCIT_R41 NCIT_C25796 @default.
- NCIT_C20599 NCIT_R41 NCIT_C79740 @default.
- NCIT_C20599 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C20599 referenceCount "7" @default.
- NCIT_C20599 hasExactSynonym "TBP Inhibitor Gene" @default.
- NCIT_C20599 type Class @default.
- NCIT_C20599 isDefinedBy ncit.owl @default.
- NCIT_C20599 label "TBP Inhibitor Gene" @default.
- NCIT_C20599 subClassOf NCIT_C16612 @default.
- NCIT_C20599 subClassOf NCIT_C20420 @default.
- NCIT_C20599 subClassOf NCIT_C20599 @default.
- NCIT_C20599 subClassOf NCIT_C54362 @default.