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- NCIT_C2062 IAO_0000115 "An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities. LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation. This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation. (NCI04)" @default.
- NCIT_C2062 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2062 NCIT_NHC0 "C2062" @default.
- NCIT_C2062 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2062 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2062 NCIT_P108 "Pan-RAR Agonist/AP-1 Inhibitor LGD 1550" @default.
- NCIT_C2062 NCIT_P207 "C1517688" @default.
- NCIT_C2062 NCIT_P210 "178600-20-9" @default.
- NCIT_C2062 NCIT_P322 "GDC" @default.
- NCIT_C2062 NCIT_P366 "LGD_1550" @default.
- NCIT_C2062 NCIT_P375 "Pan-RAR Agonist/AP-1 Inhibitor LGD 1550" @default.
- NCIT_C2062 normalizedInformationContent "100" @default.
- NCIT_C2062 referenceCount "1" @default.
- NCIT_C2062 hasExactSynonym "(2E,4E,6E)-7-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic Acid" @default.
- NCIT_C2062 hasExactSynonym "LGD 1550" @default.
- NCIT_C2062 hasExactSynonym "Pan-RAR Agonist/AP-1 Inhibitor LGD 1550" @default.
- NCIT_C2062 inSubset NCIT_C128784 @default.
- NCIT_C2062 inSubset NCIT_C157711 @default.
- NCIT_C2062 inSubset NCIT_C157712 @default.
- NCIT_C2062 inSubset NCIT_C177537 @default.
- NCIT_C2062 type Class @default.
- NCIT_C2062 isDefinedBy ncit.owl @default.
- NCIT_C2062 label "Pan-RAR Agonist/AP-1 Inhibitor LGD 1550" @default.
- NCIT_C2062 subClassOf NCIT_C129820 @default.
- NCIT_C2062 subClassOf NCIT_C163758 @default.
- NCIT_C2062 subClassOf NCIT_C1908 @default.
- NCIT_C2062 subClassOf NCIT_C1909 @default.
- NCIT_C2062 subClassOf NCIT_C1934 @default.
- NCIT_C2062 subClassOf NCIT_C2062 @default.
- NCIT_C2062 subClassOf NCIT_C2122 @default.
- NCIT_C2062 subClassOf NCIT_C274 @default.
- NCIT_C2062 subClassOf NCIT_C308 @default.
- NCIT_C2062 subClassOf NCIT_C804 @default.