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- NCIT_C20709 IAO_0000115 "Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI)" @default.
- NCIT_C20709 NCIT_NHC0 "C20709" @default.
- NCIT_C20709 NCIT_P106 "Gene or Genome" @default.
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- NCIT_C20709 hasExactSynonym "Nuclear Receptor Gene" @default.
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