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- NCIT_C20959 IAO_0000115 "G1/S-specific cyclin-E2 (404 aa, ~47 kDa) is encoded by the human CCNE2 gene. This protein plays a role in cell cycle checkpoint regulation between the G1 and S phases." @default.
- NCIT_C20959 NCIT_NHC0 "C20959" @default.
- NCIT_C20959 NCIT_P100 "603775" @default.
- NCIT_C20959 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20959 NCIT_P107 "G1/S-Specific Cyclin-E2" @default.
- NCIT_C20959 NCIT_P108 "G1/S-Specific Cyclin-E2" @default.
- NCIT_C20959 NCIT_P207 "C1611477" @default.
- NCIT_C20959 NCIT_P322 "CTRP" @default.
- NCIT_C20959 NCIT_P366 "Cyclin-E2" @default.
- NCIT_C20959 NCIT_P93 "O96020" @default.
- NCIT_C20959 NCIT_P98 "Cyclin E1, a protein encoded by the CCNE1 gene, forms a complex with and functions as a regulatory subunit of CDK2, whose activity is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 accumulates at the G1-S phase boundary and phosphorylation by CDK2 triggers its release from CDK2 and degradation. Overexpression of this gene is observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis. Cyclin E1 is associated with and involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two isoforms, E1L and E1S, are produced by alternative splicing and E1S cannot complex with CDK2. Cyclin E1 is highly expressed in testis and placenta with low levels in bronchial epithelial cells." @default.
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- NCIT_C20959 NCIT_R54 NCIT_C16612 @default.
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- NCIT_C20959 NCIT_R54 NCIT_C20958 @default.
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- NCIT_C20959 normalizedInformationContent "100" @default.
- NCIT_C20959 referenceCount "1" @default.
- NCIT_C20959 hasExactSynonym "CCNE2 Protein" @default.
- NCIT_C20959 hasExactSynonym "CCNE2" @default.
- NCIT_C20959 hasExactSynonym "Cyclin E2" @default.
- NCIT_C20959 hasExactSynonym "Cyclin-E2" @default.
- NCIT_C20959 hasExactSynonym "G1/S-Specific Cyclin E2" @default.
- NCIT_C20959 hasExactSynonym "G1/S-Specific Cyclin-E2" @default.
- NCIT_C20959 inSubset NCIT_C116977 @default.
- NCIT_C20959 inSubset NCIT_C142799 @default.
- NCIT_C20959 inSubset NCIT_C142800 @default.
- NCIT_C20959 type Class @default.
- NCIT_C20959 isDefinedBy ncit.owl @default.
- NCIT_C20959 label "G1/S-Specific Cyclin-E2" @default.
- NCIT_C20959 subClassOf NCIT_C17021 @default.
- NCIT_C20959 subClassOf NCIT_C17349 @default.
- NCIT_C20959 subClassOf NCIT_C17761 @default.
- NCIT_C20959 subClassOf NCIT_C18466 @default.
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- NCIT_C20959 subClassOf NCIT_C20959 @default.
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- NCIT_C20959 equivalentClass B9ddb89849c751f5f49afd675aa9cdce7 @default.
- NCIT_C20959 equivalentClass Babba5893b9da29a065df3f08105b4749 @default.