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- NCIT_C20986 IAO_0000115 "Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins are stable secretory polypeptides expressed in gastrointestinal mucosa that have at least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The exact function has not been determined, but TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition and reducing apoptosis. Strong expression is also found in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155, OMIM 113710, and NCI)" @default.
- NCIT_C20986 NCIT_NHC0 "C20986" @default.
- NCIT_C20986 NCIT_P100 "113710" @default.
- NCIT_C20986 NCIT_P102 "NM_003225" @default.
- NCIT_C20986 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20986 NCIT_P108 "Trefoil Factor 1" @default.
- NCIT_C20986 NCIT_P200 "Protein with Unknown or Unclassified Function" @default.
- NCIT_C20986 NCIT_P203 "Gene_Product_Kind" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Encoded_by_Gene|TFF1 Gene" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Expressed_In_Tissue|Duodenum" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Expressed_In_Tissue|Epithelial Cell" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Expressed_In_Tissue|Gastrointestinal System" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Expressed_In_Tissue|Stomach" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Has_Organism_Source|Human" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Has_Structural_Domain_Or_Motif|Trefoil Motif" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process|Regeneration" @default.
- NCIT_C20986 NCIT_P204 "Gene_Product_is_Biomarker_Type|Prognostic Factor" @default.
- NCIT_C20986 NCIT_P310 "Retired_Concept" @default.
- NCIT_C20986 NCIT_P93 "P04155" @default.
- NCIT_C20986 normalizedInformationContent "100" @default.
- NCIT_C20986 referenceCount "1" @default.
- NCIT_C20986 hasExactSynonym "Breast Cancer Estrogen-Inducible Protein" @default.
- NCIT_C20986 hasExactSynonym "Gastrointestinal Trefoil Protein pS2" @default.
- NCIT_C20986 hasExactSynonym "TFF1" @default.
- NCIT_C20986 hasExactSynonym "Tefoil Protein 1" @default.
- NCIT_C20986 hasExactSynonym "Trefoil Factor 1" @default.
- NCIT_C20986 hasExactSynonym "Trefoil Protein 1" @default.
- NCIT_C20986 type Class @default.
- NCIT_C20986 isDefinedBy ncit.owl @default.
- NCIT_C20986 label "Trefoil Factor 1" @default.
- NCIT_C20986 subClassOf NCIT_C20986 @default.
- NCIT_C20986 subClassOf NCIT_C28428 @default.
- NCIT_C20986 subClassOf NCIT_C83480 @default.
- NCIT_C20986 deprecated "true" @default.