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- NCIT_C21208 IAO_0000115 "Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)" @default.
- NCIT_C21208 NCIT_NHC0 "C21208" @default.
- NCIT_C21208 NCIT_P100 "601593" @default.
- NCIT_C21208 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C21208 NCIT_P106 "Biologically Active Substance" @default.
- NCIT_C21208 NCIT_P108 "BRCA1 Associated RING Domain Protein 1" @default.
- NCIT_C21208 NCIT_P200 "Tumor Suppressor Protein" @default.
- NCIT_C21208 NCIT_P203 "Protein_Kind" @default.
- NCIT_C21208 NCIT_P204 "Protein_Encoded_by_Gene|BARD1 Gene" @default.
- NCIT_C21208 NCIT_P204 "Protein_Has_Associated_Anatomy|Nucleus" @default.
- NCIT_C21208 NCIT_P204 "Protein_Has_Structural_Domain_Or_Motif|Ankyrin Repeat" @default.
- NCIT_C21208 NCIT_P204 "Protein_Has_Structural_Domain_Or_Motif|BRCT Domain" @default.
- NCIT_C21208 NCIT_P204 "Protein_Has_Structural_Domain_Or_Motif|Ring Finger Domain" @default.
- NCIT_C21208 NCIT_P204 "Protein_Malfunction_Associated_With_Disease|Breast Carcinoma" @default.
- NCIT_C21208 NCIT_P204 "Protein_Malfunction_Associated_With_Disease|Ovarian Carcinoma" @default.
- NCIT_C21208 NCIT_P204 "Protein_Malfunction_Associated_With_Disease|Uterine Neoplasm" @default.
- NCIT_C21208 NCIT_P204 "Protein_Plays_Role_In_Biological_Process|Tumor Suppression" @default.
- NCIT_C21208 NCIT_P310 "Retired_Concept" @default.
- NCIT_C21208 NCIT_P93 "Q99728" @default.
- NCIT_C21208 NCIT_P98 "Use 'BRCA1 Associated RING Domain 1 Protein'" @default.
- NCIT_C21208 normalizedInformationContent "100" @default.
- NCIT_C21208 referenceCount "1" @default.
- NCIT_C21208 hasExactSynonym "BARD1 Protein" @default.
- NCIT_C21208 hasExactSynonym "BRCA1 Associated RING Domain 1" @default.
- NCIT_C21208 hasExactSynonym "BRCA1 Associated RING Domain Protein 1" @default.
- NCIT_C21208 hasExactSynonym "BRCA1-Associated RING Domain 1" @default.
- NCIT_C21208 type Class @default.
- NCIT_C21208 isDefinedBy ncit.owl @default.
- NCIT_C21208 label "BRCA1 Associated RING Domain Protein 1" @default.
- NCIT_C21208 subClassOf NCIT_C21208 @default.
- NCIT_C21208 subClassOf NCIT_C28428 @default.
- NCIT_C21208 subClassOf NCIT_C83479 @default.
- NCIT_C21208 deprecated "true" @default.