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- NCIT_C21256 IAO_0000115 "The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)" @default.
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- NCIT_C21256 referenceCount "4" @default.
- NCIT_C21256 hasExactSynonym "14-3-3 Family" @default.
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