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- NCIT_C2130 IAO_0000115 "Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis." @default.
- NCIT_C2130 NCIT_NHC0 "C2130" @default.
- NCIT_C2130 NCIT_P106 "Chemical Viewed Functionally" @default.
- NCIT_C2130 NCIT_P108 "Gamma-Glutamylcysteine Synthetase Inhibitor" @default.
- NCIT_C2130 NCIT_P207 "C1517431" @default.
- NCIT_C2130 NCIT_P366 "Gamma-Glutamylcysteine_Synthetase_Inhibitor" @default.
- NCIT_C2130 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C2130 referenceCount "3" @default.
- NCIT_C2130 hasExactSynonym "GCS Inhibitors" @default.
- NCIT_C2130 hasExactSynonym "Gamma-Glutamylcysteine Synthetase Inhibitor" @default.
- NCIT_C2130 hasExactSynonym "Glutamate-cysteine Ligase Inhibitor" @default.
- NCIT_C2130 hasExactSynonym "Glutathione Synthesis Inhibitors" @default.
- NCIT_C2130 type Class @default.
- NCIT_C2130 isDefinedBy ncit.owl @default.
- NCIT_C2130 label "Gamma-Glutamylcysteine Synthetase Inhibitor" @default.
- NCIT_C2130 subClassOf NCIT_C1908 @default.
- NCIT_C2130 subClassOf NCIT_C1909 @default.
- NCIT_C2130 subClassOf NCIT_C2130 @default.
- NCIT_C2130 subClassOf NCIT_C471 @default.