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• NCIT_C21446 IAO_0000115 "General transcription and DNA repair factor IIH helicase subunit XPD (760 aa, ~87 kDa) is encoded by the human ERCC2 gene. This protein plays a role in DNA helicase activity, RNA polymerase II-mediated transcription and nucleotide excision repair." @default.
• NCIT_C21446 NCIT_NHC0 "C21446" @default.
• NCIT_C21446 NCIT_P100 "126340" @default.
• NCIT_C21446 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
• NCIT_C21446 NCIT_P106 "Enzyme" @default.
• NCIT_C21446 NCIT_P107 "TFIIH Basal Transcription Factor Complex Helicase XPD Subunit" @default.
• NCIT_C21446 NCIT_P108 "General Transcription and DNA Repair Factor IIH Helicase Subunit XPD" @default.
• NCIT_C21446 NCIT_P207 "C0168552" @default.
• NCIT_C21446 NCIT_P322 "CTRP" @default.
• NCIT_C21446 NCIT_P366 "DNA_Excision_Repair_Protein-ERCC2" @default.
• NCIT_C21446 NCIT_P93 "P18074" @default.
• NCIT_C21446 NCIT_P98 "TFIIH basal transcription factor complex helicase XPD subunit is an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome." @default.
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