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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C21598> ?p ?o ?g. }

Showing items 1 to 100 of ±108 with 100 items per page.

NCIT_C21598 IAO_0000115 "Gastrin/cholecystokinin type B receptor (447 aa, ~48 kDa) is encoded by the human CCKBR gene. This protein is involved in peptide hormone binding and the regulation of cell proliferation, feeding behavior, and sensory perception." @default.
NCIT_C21598 NCIT_NHC0 "C21598" @default.
NCIT_C21598 NCIT_P100 "118445" @default.
NCIT_C21598 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
NCIT_C21598 NCIT_P106 "Receptor" @default.
NCIT_C21598 NCIT_P107 "Gastrin/Cholecystokinin Type B Receptor" @default.
NCIT_C21598 NCIT_P108 "Gastrin/Cholecystokinin Type B Receptor" @default.
NCIT_C21598 NCIT_P207 "C0248266" @default.
NCIT_C21598 NCIT_P322 "CTRP" @default.
NCIT_C21598 NCIT_P366 "Cholecystokinin-B_Receptor" @default.
NCIT_C21598 NCIT_P93 "P32239" @default.
NCIT_C21598 NCIT_P98 "Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR), encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)" @default.
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NCIT_C21598 hasExactSynonym "CCK-B Receptor" @default.
NCIT_C21598 hasExactSynonym "CCK-BR" @default.
NCIT_C21598 hasExactSynonym "CCK2-R" @default.
NCIT_C21598 hasExactSynonym "CCKBR" @default.
NCIT_C21598 hasExactSynonym "CCKRB" @default.
NCIT_C21598 hasExactSynonym "Cholecystokinin B Receptor" @default.
NCIT_C21598 hasExactSynonym "Cholecystokinin Type B Receptor" @default.
NCIT_C21598 hasExactSynonym "Cholecystokinin-2 Receptor" @default.
NCIT_C21598 hasExactSynonym "GASR" @default.
NCIT_C21598 hasExactSynonym "Gastrin Receptor" @default.
NCIT_C21598 hasExactSynonym "Gastrin/Cholecystokinin Type B Receptor" @default.
NCIT_C21598 inSubset NCIT_C116977 @default.
NCIT_C21598 inSubset NCIT_C142799 @default.
NCIT_C21598 inSubset NCIT_C142800 @default.
NCIT_C21598 type Class @default.
NCIT_C21598 isDefinedBy ncit.owl @default.
NCIT_C21598 label "Gastrin/Cholecystokinin Type B Receptor" @default.
NCIT_C21598 subClassOf NCIT_C17021 @default.