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- NCIT_C2221 IAO_0000115 "A recombinant and modified form of the endogenous cytokine human interferon (IFN) beta-1b, with antiproliferative, antiviral and immunomodulating activities. Upon administration, interferon beta-1b targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1b is produced following viral infection and it plays a key role in innate immune response against viral pathogens." @default.
- NCIT_C2221 NCIT_NHC0 "C2221" @default.
- NCIT_C2221 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2221 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2221 NCIT_P108 "Interferon Beta-1B" @default.
- NCIT_C2221 NCIT_P175 "660166" @default.
- NCIT_C2221 NCIT_P207 "C0244714" @default.
- NCIT_C2221 NCIT_P210 "145155-23-3" @default.
- NCIT_C2221 NCIT_P319 "TTD90R31WZ" @default.
- NCIT_C2221 NCIT_P322 "FDA" @default.
- NCIT_C2221 NCIT_P366 "Interferon_Beta-1B" @default.
- NCIT_C2221 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2221 NCIT_R124 NCIT_C18992 @default.
- NCIT_C2221 NCIT_R124 NCIT_C19143 @default.
- NCIT_C2221 NCIT_R124 NCIT_C21124 @default.
- NCIT_C2221 NCIT_R124 NCIT_C40702 @default.
- NCIT_C2221 NCIT_R124 NCIT_C45547 @default.
- NCIT_C2221 NCIT_R125 NCIT_C17710 @default.
- NCIT_C2221 NCIT_R125 NCIT_C17828 @default.
- NCIT_C2221 NCIT_R125 NCIT_C17937 @default.
- NCIT_C2221 NCIT_R125 NCIT_C18081 @default.
- NCIT_C2221 NCIT_R125 NCIT_C18095 @default.
- NCIT_C2221 NCIT_R125 NCIT_C18839 @default.
- NCIT_C2221 NCIT_R125 NCIT_C20480 @default.
- NCIT_C2221 NCIT_R125 NCIT_C20751 @default.
- NCIT_C2221 NCIT_R125 NCIT_C21049 @default.
- NCIT_C2221 NCIT_R125 NCIT_C21050 @default.
- NCIT_C2221 NCIT_R125 NCIT_C21124 @default.
- NCIT_C2221 NCIT_R125 NCIT_C28498 @default.
- NCIT_C2221 NCIT_R125 NCIT_C40912 @default.
- NCIT_C2221 NCIT_R146 NCIT_C21176 @default.
- NCIT_C2221 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2221 NCIT_R146 NCIT_C37274 @default.
- NCIT_C2221 normalizedInformationContent "100" @default.
- NCIT_C2221 referenceCount "1" @default.
- NCIT_C2221 hasExactSynonym "Beta-ser-interferon" @default.
- NCIT_C2221 hasExactSynonym "Betaferon" @default.
- NCIT_C2221 hasExactSynonym "Betaseron" @default.
- NCIT_C2221 hasExactSynonym "INTERFERON BETA-1B" @default.
- NCIT_C2221 hasExactSynonym "Interferon Beta-1B" @default.
- NCIT_C2221 hasExactSynonym "Recombinant interferon beta-1b" @default.
- NCIT_C2221 inSubset NCIT_C173381 @default.
- NCIT_C2221 inSubset NCIT_C173383 @default.
- NCIT_C2221 inSubset NCIT_C63923 @default.
- NCIT_C2221 type Class @default.
- NCIT_C2221 isDefinedBy ncit.owl @default.
- NCIT_C2221 label "Interferon Beta-1B" @default.
- NCIT_C2221 subClassOf NCIT_C1283 @default.
- NCIT_C2221 subClassOf NCIT_C1908 @default.
- NCIT_C2221 subClassOf NCIT_C1909 @default.
- NCIT_C2221 subClassOf NCIT_C2221 @default.
- NCIT_C2221 subClassOf NCIT_C307 @default.
- NCIT_C2221 subClassOf NCIT_C308 @default.
- NCIT_C2221 subClassOf NCIT_C495 @default.
- NCIT_C2221 subClassOf NCIT_C584 @default.