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- NCIT_C2223 IAO_0000115 "An iodine 131 labeled radioimmunoconjugate of monoclonal antibody (MOAB) TNT-1/B with radioimaging and antineoplastic properties. MOAB TNT-1/B was developed for radioimmunotherapy of solid tumors, designated as Tumor Necrosis Treatment (TNT). TNT exploits the presence of degenerating and necrotic cells within tumors by utilizing MOAbs directed against universal, intracellular nucleosomal determinants consisting of histone H1 and DNA. This MOAB was conjugated with biotin (B) molecules, which increase pharmacokinetic performance of the monoclonal antibody. Upon administration, iodine I 131 derlotuximab biotin delivers I 131 to tumor cells and results in the targeted imaging and/or destruction of cells with exposed necrotic antigens." @default.
- NCIT_C2223 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2223 NCIT_NHC0 "C2223" @default.
- NCIT_C2223 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2223 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2223 NCIT_P107 "Iodine I 131 Derlotuximab Biotin" @default.
- NCIT_C2223 NCIT_P108 "Iodine I 131 Derlotuximab Biotin" @default.
- NCIT_C2223 NCIT_P207 "C0879273" @default.
- NCIT_C2223 NCIT_P210 "340013-96-9" @default.
- NCIT_C2223 NCIT_P319 "1724UJB90B" @default.
- NCIT_C2223 NCIT_P322 "CTRP" @default.
- NCIT_C2223 NCIT_P322 "FDA" @default.
- NCIT_C2223 NCIT_P322 "GDC" @default.
- NCIT_C2223 NCIT_P329 "43561" @default.
- NCIT_C2223 NCIT_P330 "43561" @default.
- NCIT_C2223 NCIT_P366 "I_131_Monoclonal_Antibody_TNT-1_B" @default.
- NCIT_C2223 NCIT_P375 "Iodine I 131 Derlotuximab Biotin" @default.
- NCIT_C2223 NCIT_P399 "43561" @default.
- NCIT_C2223 normalizedInformationContent "100" @default.
- NCIT_C2223 referenceCount "1" @default.
- NCIT_C2223 hasExactSynonym "Cotara" @default.
- NCIT_C2223 hasExactSynonym "I 131 MOAB TNT-1/B" @default.
- NCIT_C2223 hasExactSynonym "I 131 Monoclonal Antibody TNT-1/B" @default.
- NCIT_C2223 hasExactSynonym "IODINE I-131 DERLOTUXIMAB BIOTIN" @default.
- NCIT_C2223 hasExactSynonym "Iodine I 131 Derlotuximab Biotin" @default.
- NCIT_C2223 hasExactSynonym "iodine I 131 MOAB TNT-1/B" @default.
- NCIT_C2223 inSubset NCIT_C116977 @default.
- NCIT_C2223 inSubset NCIT_C116978 @default.
- NCIT_C2223 inSubset NCIT_C128784 @default.
- NCIT_C2223 inSubset NCIT_C157711 @default.
- NCIT_C2223 inSubset NCIT_C157712 @default.
- NCIT_C2223 inSubset NCIT_C176424 @default.
- NCIT_C2223 inSubset NCIT_C177537 @default.
- NCIT_C2223 inSubset NCIT_C63923 @default.
- NCIT_C2223 type Class @default.
- NCIT_C2223 isDefinedBy ncit.owl @default.
- NCIT_C2223 label "Iodine I 131 Derlotuximab Biotin" @default.
- NCIT_C2223 subClassOf NCIT_C129819 @default.
- NCIT_C2223 subClassOf NCIT_C1446 @default.
- NCIT_C2223 subClassOf NCIT_C1511 @default.
- NCIT_C2223 subClassOf NCIT_C1512 @default.
- NCIT_C2223 subClassOf NCIT_C1908 @default.
- NCIT_C2223 subClassOf NCIT_C1909 @default.
- NCIT_C2223 subClassOf NCIT_C2124 @default.
- NCIT_C2223 subClassOf NCIT_C2223 @default.
- NCIT_C2223 subClassOf NCIT_C274 @default.
- NCIT_C2223 subClassOf NCIT_C307 @default.
- NCIT_C2223 subClassOf NCIT_C308 @default.