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- NCIT_C2233 IAO_0000115 "An isothiocyanate found in cruciferous vegetables with chemopreventive and potential antitumor activities. Although the mechanism of action is unclear, phenethyl Isothiocyanate (PEITC) was shown to induce apoptosis in tumor cells, possibly mediated through its metabolic intermediates, reactive oxygen species (ROS). PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma." @default.
- NCIT_C2233 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2233 NCIT_NHC0 "C2233" @default.
- NCIT_C2233 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2233 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2233 NCIT_P107 "Phenethyl Isothiocyanate" @default.
- NCIT_C2233 NCIT_P108 "Phenethyl Isothiocyanate" @default.
- NCIT_C2233 NCIT_P171 "16921492" @default.
- NCIT_C2233 NCIT_P175 "87868" @default.
- NCIT_C2233 NCIT_P207 "C0070558" @default.
- NCIT_C2233 NCIT_P210 "2257-09-2" @default.
- NCIT_C2233 NCIT_P319 "6U7TFK75KV" @default.
- NCIT_C2233 NCIT_P322 "CTRP" @default.
- NCIT_C2233 NCIT_P322 "FDA" @default.
- NCIT_C2233 NCIT_P322 "GDC" @default.
- NCIT_C2233 NCIT_P325 "A substance being studied in the prevention of cancer. It is a naturally occurring compound found in some cruciferous vegetables." @default.
- NCIT_C2233 NCIT_P329 "37977" @default.
- NCIT_C2233 NCIT_P330 "37977" @default.
- NCIT_C2233 NCIT_P350 "C9H9NS" @default.
- NCIT_C2233 NCIT_P366 "Phenethyl_Isothiocyanate" @default.
- NCIT_C2233 NCIT_P368 "CHEBI:351346" @default.
- NCIT_C2233 NCIT_P375 "Phenethyl Isothiocyanate" @default.
- NCIT_C2233 NCIT_P399 "37977" @default.
- NCIT_C2233 normalizedInformationContent "100" @default.
- NCIT_C2233 referenceCount "1" @default.
- NCIT_C2233 hasExactSynonym "(2-Isothiocyanatoethyl)benzene" @default.
- NCIT_C2233 hasExactSynonym "2-Phenylethyl Isothiocyanate" @default.
- NCIT_C2233 hasExactSynonym "PEITC" @default.
- NCIT_C2233 hasExactSynonym "PHENETHYL ISOTHIOCYANATE" @default.
- NCIT_C2233 hasExactSynonym "Phenethyl Isothiocyanate" @default.
- NCIT_C2233 hasExactSynonym "Phenethyl isothiocyanate" @default.
- NCIT_C2233 hasExactSynonym "phenethyl isothiocyanate" @default.
- NCIT_C2233 inSubset NCIT_C116977 @default.
- NCIT_C2233 inSubset NCIT_C116978 @default.
- NCIT_C2233 inSubset NCIT_C128784 @default.
- NCIT_C2233 inSubset NCIT_C157711 @default.
- NCIT_C2233 inSubset NCIT_C157712 @default.
- NCIT_C2233 inSubset NCIT_C176424 @default.
- NCIT_C2233 inSubset NCIT_C177537 @default.
- NCIT_C2233 inSubset NCIT_C63923 @default.
- NCIT_C2233 type Class @default.
- NCIT_C2233 isDefinedBy ncit.owl @default.
- NCIT_C2233 label "Phenethyl Isothiocyanate" @default.
- NCIT_C2233 subClassOf NCIT_C1892 @default.
- NCIT_C2233 subClassOf NCIT_C1908 @default.
- NCIT_C2233 subClassOf NCIT_C1909 @default.
- NCIT_C2233 subClassOf NCIT_C1913 @default.
- NCIT_C2233 subClassOf NCIT_C1930 @default.
- NCIT_C2233 subClassOf NCIT_C1949 @default.
- NCIT_C2233 subClassOf NCIT_C2233 @default.
- NCIT_C2233 subClassOf NCIT_C45496 @default.
- NCIT_C2233 subClassOf NCIT_C45711 @default.
- NCIT_C2233 subClassOf NCIT_C54060 @default.
- NCIT_C2233 subClassOf NCIT_C54630 @default.
- NCIT_C2233 subClassOf NCIT_C718 @default.