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- NCIT_C225 IAO_0000115 "A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)" @default.
- NCIT_C225 NCIT_A32 NCIT_C1909 @default.
- NCIT_C225 NCIT_NHC0 "C225" @default.
- NCIT_C225 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C225 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C225 NCIT_P107 "Recombinant Interferon Alfa" @default.
- NCIT_C225 NCIT_P108 "Recombinant Interferon Alfa" @default.
- NCIT_C225 NCIT_P207 "C0002199" @default.
- NCIT_C225 NCIT_P302 "See specific agents." @default.
- NCIT_C225 NCIT_P322 "CTRP" @default.
- NCIT_C225 NCIT_P322 "GDC" @default.
- NCIT_C225 NCIT_P329 "40467" @default.
- NCIT_C225 NCIT_P330 "40467" @default.
- NCIT_C225 NCIT_P366 "Therapeutic_Interferon_Alfa" @default.
- NCIT_C225 NCIT_P375 "Recombinant Interferon Alfa" @default.
- NCIT_C225 NCIT_P399 "40467" @default.
- NCIT_C225 normalizedInformationContent "65.823773834699878" @default.
- NCIT_C225 referenceCount "175" @default.
- NCIT_C225 hasExactSynonym "Alferon" @default.
- NCIT_C225 hasExactSynonym "Alpha Interferon" @default.
- NCIT_C225 hasExactSynonym "Interferon Alfa" @default.
- NCIT_C225 hasExactSynonym "Leukocyte Interferon" @default.
- NCIT_C225 hasExactSynonym "Lymphoblast Interferon" @default.
- NCIT_C225 hasExactSynonym "Lymphoblastoid Interferon" @default.
- NCIT_C225 hasExactSynonym "Recombinant Interferon Alfa" @default.
- NCIT_C225 hasExactSynonym "alpha-Interferon" @default.
- NCIT_C225 inSubset NCIT_C116977 @default.
- NCIT_C225 inSubset NCIT_C116978 @default.
- NCIT_C225 inSubset NCIT_C128784 @default.
- NCIT_C225 inSubset NCIT_C157711 @default.
- NCIT_C225 inSubset NCIT_C157712 @default.
- NCIT_C225 inSubset NCIT_C173381 @default.
- NCIT_C225 inSubset NCIT_C173383 @default.
- NCIT_C225 inSubset NCIT_C176424 @default.
- NCIT_C225 inSubset NCIT_C177537 @default.
- NCIT_C225 type Class @default.
- NCIT_C225 isDefinedBy ncit.owl @default.
- NCIT_C225 label "Recombinant Interferon Alfa" @default.
- NCIT_C225 subClassOf NCIT_C1283 @default.
- NCIT_C225 subClassOf NCIT_C1742 @default.
- NCIT_C225 subClassOf NCIT_C1908 @default.
- NCIT_C225 subClassOf NCIT_C1909 @default.
- NCIT_C225 subClassOf NCIT_C1971 @default.
- NCIT_C225 subClassOf NCIT_C225 @default.
- NCIT_C225 subClassOf NCIT_C274 @default.
- NCIT_C225 subClassOf NCIT_C307 @default.
- NCIT_C225 subClassOf NCIT_C308 @default.
- NCIT_C225 subClassOf NCIT_C584 @default.