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- NCIT_C2251 IAO_0000115 "A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, iroplact inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types." @default.
- NCIT_C2251 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2251 NCIT_NHC0 "C2251" @default.
- NCIT_C2251 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2251 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2251 NCIT_P108 "Iroplact" @default.
- NCIT_C2251 NCIT_P175 "671662" @default.
- NCIT_C2251 NCIT_P207 "C3887655" @default.
- NCIT_C2251 NCIT_P210 "37270-94-3" @default.
- NCIT_C2251 NCIT_P319 "T381WW8L8Y" @default.
- NCIT_C2251 NCIT_P322 "FDA" @default.
- NCIT_C2251 NCIT_P322 "GDC" @default.
- NCIT_C2251 NCIT_P329 "42317" @default.
- NCIT_C2251 NCIT_P330 "42317" @default.
- NCIT_C2251 NCIT_P366 "Therapeutic_Platelet_Factor_4" @default.
- NCIT_C2251 NCIT_P375 "Iroplact" @default.
- NCIT_C2251 NCIT_P375 "Recombinant Platelet Factor 4" @default.
- NCIT_C2251 NCIT_P399 "42317" @default.
- NCIT_C2251 normalizedInformationContent "100" @default.
- NCIT_C2251 referenceCount "1" @default.
- NCIT_C2251 hasExactSynonym "IROPLACT" @default.
- NCIT_C2251 hasExactSynonym "Iroplact" @default.
- NCIT_C2251 hasExactSynonym "Recombinant CXCL4" @default.
- NCIT_C2251 hasExactSynonym "Recombinant Platelet Factor 4" @default.
- NCIT_C2251 hasExactSynonym "rPF4" @default.
- NCIT_C2251 hasExactSynonym "rhPF4" @default.
- NCIT_C2251 inSubset NCIT_C128784 @default.
- NCIT_C2251 inSubset NCIT_C157711 @default.
- NCIT_C2251 inSubset NCIT_C157712 @default.
- NCIT_C2251 inSubset NCIT_C176424 @default.
- NCIT_C2251 inSubset NCIT_C177537 @default.
- NCIT_C2251 inSubset NCIT_C63923 @default.
- NCIT_C2251 type Class @default.
- NCIT_C2251 isDefinedBy ncit.owl @default.
- NCIT_C2251 label "Iroplact" @default.
- NCIT_C2251 subClassOf NCIT_C1283 @default.
- NCIT_C2251 subClassOf NCIT_C1592 @default.
- NCIT_C2251 subClassOf NCIT_C1593 @default.
- NCIT_C2251 subClassOf NCIT_C1742 @default.
- NCIT_C2251 subClassOf NCIT_C1908 @default.
- NCIT_C2251 subClassOf NCIT_C1909 @default.
- NCIT_C2251 subClassOf NCIT_C2251 @default.
- NCIT_C2251 subClassOf NCIT_C274 @default.
- NCIT_C2251 subClassOf NCIT_C307 @default.
- NCIT_C2251 subClassOf NCIT_C308 @default.