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- NCIT_C226 IAO_0000115 "A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)" @default.
- NCIT_C226 NCIT_A32 NCIT_C1909 @default.
- NCIT_C226 NCIT_A5 NCIT_C1579 @default.
- NCIT_C226 NCIT_A7 NCIT_C38931 @default.
- NCIT_C226 NCIT_NHC0 "C226" @default.
- NCIT_C226 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C226 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C226 NCIT_P107 "Eflornithine" @default.
- NCIT_C226 NCIT_P108 "Eflornithine" @default.
- NCIT_C226 NCIT_P207 "C0002260" @default.
- NCIT_C226 NCIT_P210 "67037-37-0" @default.
- NCIT_C226 NCIT_P210 "70052-12-9" @default.
- NCIT_C226 NCIT_P302 "Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection" @default.
- NCIT_C226 NCIT_P319 "ZQN1G5V6SR" @default.
- NCIT_C226 NCIT_P322 "CTRP" @default.
- NCIT_C226 NCIT_P322 "FDA" @default.
- NCIT_C226 NCIT_P322 "GDC" @default.
- NCIT_C226 NCIT_P325 "A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals." @default.
- NCIT_C226 NCIT_P329 "39754" @default.
- NCIT_C226 NCIT_P330 "39754" @default.
- NCIT_C226 NCIT_P350 "C6H12F2N2O2" @default.
- NCIT_C226 NCIT_P366 "Eflornithine" @default.
- NCIT_C226 NCIT_P368 "CHEBI:41948" @default.
- NCIT_C226 NCIT_P375 "Eflornithine" @default.
- NCIT_C226 NCIT_P399 "39754" @default.
- NCIT_C226 NCIT_R124 NCIT_C17710 @default.
- NCIT_C226 NCIT_R124 NCIT_C17828 @default.
- NCIT_C226 NCIT_R124 NCIT_C28498 @default.
- NCIT_C226 NCIT_R124 NCIT_C40576 @default.
- NCIT_C226 NCIT_R124 NCIT_C40577 @default.
- NCIT_C226 NCIT_R125 NCIT_C17557 @default.
- NCIT_C226 NCIT_R125 NCIT_C17710 @default.
- NCIT_C226 NCIT_R125 NCIT_C17828 @default.
- NCIT_C226 NCIT_R125 NCIT_C18081 @default.
- NCIT_C226 NCIT_R125 NCIT_C19536 @default.
- NCIT_C226 NCIT_R125 NCIT_C20480 @default.
- NCIT_C226 NCIT_R125 NCIT_C20751 @default.
- NCIT_C226 NCIT_R125 NCIT_C28498 @default.
- NCIT_C226 NCIT_R125 NCIT_C40625 @default.
- NCIT_C226 NCIT_R125 NCIT_C40671 @default.
- NCIT_C226 NCIT_R125 NCIT_C41515 @default.
- NCIT_C226 NCIT_R146 NCIT_C16554 @default.
- NCIT_C226 NCIT_R146 NCIT_C16804 @default.
- NCIT_C226 NCIT_R146 NCIT_C17021 @default.
- NCIT_C226 NCIT_R146 NCIT_C20027 @default.
- NCIT_C226 NCIT_R146 NCIT_C26548 @default.
- NCIT_C226 NCIT_R146 NCIT_C38931 @default.
- NCIT_C226 normalizedInformationContent "85.460608731874885" @default.
- NCIT_C226 referenceCount "9" @default.
- NCIT_C226 hasExactSynonym "2-(Difluoromethyl)-DL-ornithine" @default.
- NCIT_C226 hasExactSynonym "2-Difluoromethylornithine" @default.
- NCIT_C226 hasExactSynonym "Alpha-Difluoromethylornithine" @default.
- NCIT_C226 hasExactSynonym "D,L-alpha-Difluoromethylornithine" @default.
- NCIT_C226 hasExactSynonym "DFMO" @default.
- NCIT_C226 hasExactSynonym "Difluoromethylornithine" @default.
- NCIT_C226 hasExactSynonym "Difluromethylornithine" @default.
- NCIT_C226 hasExactSynonym "EFLORNITHINE" @default.
- NCIT_C226 hasExactSynonym "Eflornithine" @default.
- NCIT_C226 hasExactSynonym "difluoromethylornithine" @default.
- NCIT_C226 hasExactSynonym "eflornithine" @default.
- NCIT_C226 inSubset NCIT_C116977 @default.
- NCIT_C226 inSubset NCIT_C116978 @default.
- NCIT_C226 inSubset NCIT_C128784 @default.
- NCIT_C226 inSubset NCIT_C157711 @default.
- NCIT_C226 inSubset NCIT_C157712 @default.
- NCIT_C226 inSubset NCIT_C176424 @default.
- NCIT_C226 inSubset NCIT_C177537 @default.
- NCIT_C226 inSubset NCIT_C63923 @default.
- NCIT_C226 type Class @default.
- NCIT_C226 isDefinedBy ncit.owl @default.
- NCIT_C226 label "Eflornithine" @default.
- NCIT_C226 subClassOf NCIT_C129824 @default.
- NCIT_C226 subClassOf NCIT_C1908 @default.
- NCIT_C226 subClassOf NCIT_C1909 @default.
- NCIT_C226 subClassOf NCIT_C2076 @default.
- NCIT_C226 subClassOf NCIT_C2088 @default.
- NCIT_C226 subClassOf NCIT_C2189 @default.
- NCIT_C226 subClassOf NCIT_C226 @default.
- NCIT_C226 subClassOf NCIT_C274 @default.
- NCIT_C226 subClassOf NCIT_C471 @default.
- NCIT_C226 equivalentClass B793589e4552988cfc03ed621a8f8f398 @default.
- NCIT_C226 equivalentClass Bf4e507802bdd4c20d7aa963839102d42 @default.