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- NCIT_C2267 IAO_0000115 "A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters." @default.
- NCIT_C2267 NCIT_NHC0 "C2267" @default.
- NCIT_C2267 NCIT_P106 "Hormone" @default.
- NCIT_C2267 NCIT_P107 "Melatonin" @default.
- NCIT_C2267 NCIT_P108 "Melatonin" @default.
- NCIT_C2267 NCIT_P175 "113928" @default.
- NCIT_C2267 NCIT_P207 "C0025219" @default.
- NCIT_C2267 NCIT_P210 "73-31-4" @default.
- NCIT_C2267 NCIT_P322 "CTRP" @default.
- NCIT_C2267 NCIT_P325 "A hormone made by the pineal gland (tiny organ near the center of the brain). Melatonin helps control the body's sleep cycle, and is an antioxidant. It is also made in the laboratory and sold as a supplement." @default.
- NCIT_C2267 NCIT_P366 "Melatonin" @default.
- NCIT_C2267 NCIT_P368 "CHEBI:16796" @default.
- NCIT_C2267 normalizedInformationContent "100" @default.
- NCIT_C2267 referenceCount "1" @default.
- NCIT_C2267 hasExactSynonym "5-Methoxy-N-acetyltryptamine" @default.
- NCIT_C2267 hasExactSynonym "Melatonin" @default.
- NCIT_C2267 hasExactSynonym "N-Acetyl-5-methoxytryptamine" @default.
- NCIT_C2267 hasExactSynonym "N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide" @default.
- NCIT_C2267 hasExactSynonym "N-[2-(5-methoxyindol-3-yl)ethyl]acetamide" @default.
- NCIT_C2267 hasExactSynonym "melatonin" @default.
- NCIT_C2267 inSubset NCIT_C116977 @default.
- NCIT_C2267 inSubset NCIT_C142799 @default.
- NCIT_C2267 type Class @default.
- NCIT_C2267 isDefinedBy ncit.owl @default.
- NCIT_C2267 label "Melatonin" @default.
- NCIT_C2267 subClassOf NCIT_C1899 @default.
- NCIT_C2267 subClassOf NCIT_C1908 @default.
- NCIT_C2267 subClassOf NCIT_C2267 @default.
- NCIT_C2267 subClassOf NCIT_C2315 @default.