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- NCIT_C227 IAO_0000115 "A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability." @default.
- NCIT_C227 NCIT_NHC0 "C227" @default.
- NCIT_C227 NCIT_P106 "Organic Chemical" @default.
- NCIT_C227 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C227 NCIT_P108 "Alprazolam" @default.
- NCIT_C227 NCIT_P207 "C0002333" @default.
- NCIT_C227 NCIT_P210 "28981-97-7" @default.
- NCIT_C227 NCIT_P319 "YU55MQ3IZY" @default.
- NCIT_C227 NCIT_P322 "FDA" @default.
- NCIT_C227 NCIT_P325 "A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine." @default.
- NCIT_C227 NCIT_P329 "39659" @default.
- NCIT_C227 NCIT_P330 "39659" @default.
- NCIT_C227 NCIT_P350 "C17H13ClN4" @default.
- NCIT_C227 NCIT_P366 "Alprazolam" @default.
- NCIT_C227 NCIT_P368 "CHEBI:2611" @default.
- NCIT_C227 NCIT_P399 "39659" @default.
- NCIT_C227 NCIT_R122 NCIT_C16484 @default.
- NCIT_C227 NCIT_R122 NCIT_C16486 @default.
- NCIT_C227 NCIT_R122 NCIT_C16554 @default.
- NCIT_C227 NCIT_R122 NCIT_C16865 @default.
- NCIT_C227 NCIT_R122 NCIT_C16946 @default.
- NCIT_C227 NCIT_R122 NCIT_C17021 @default.
- NCIT_C227 NCIT_R122 NCIT_C17573 @default.
- NCIT_C227 NCIT_R122 NCIT_C20027 @default.
- NCIT_C227 NCIT_R122 NCIT_C26548 @default.
- NCIT_C227 NCIT_R122 NCIT_C28459 @default.
- NCIT_C227 NCIT_R122 NCIT_C45999 @default.
- NCIT_C227 NCIT_R122 NCIT_C46000 @default.
- NCIT_C227 normalizedInformationContent "100" @default.
- NCIT_C227 referenceCount "1" @default.
- NCIT_C227 hasExactSynonym "ALPRAZOLAM" @default.
- NCIT_C227 hasExactSynonym "Alprazolam" @default.
- NCIT_C227 hasExactSynonym "Apo-Alpzar" @default.
- NCIT_C227 hasExactSynonym "Nu-Alpraz" @default.
- NCIT_C227 hasExactSynonym "Xanax" @default.
- NCIT_C227 hasExactSynonym "alprazolam" @default.
- NCIT_C227 inSubset NCIT_C176424 @default.
- NCIT_C227 inSubset NCIT_C63923 @default.
- NCIT_C227 type Class @default.
- NCIT_C227 isDefinedBy ncit.owl @default.
- NCIT_C227 label "Alprazolam" @default.
- NCIT_C227 subClassOf B7fb17ab29b01a9cea924ef2e99e7a5c8 @default.
- NCIT_C227 subClassOf B81f601d47c3c5b7f0db5356dcfd265de @default.
- NCIT_C227 subClassOf B8aa2443e982cc5426964b9031b96170a @default.
- NCIT_C227 subClassOf B9152ac21f05f549346f8c01dedf8fd9a @default.
- NCIT_C227 subClassOf Bc0704b472a62215649b1e3ee27917826 @default.
- NCIT_C227 subClassOf Bf1d1aff3b8ba2221a2122f1768528b65 @default.
- NCIT_C227 subClassOf NCIT_C1012 @default.
- NCIT_C227 subClassOf NCIT_C1908 @default.
- NCIT_C227 subClassOf NCIT_C1909 @default.
- NCIT_C227 subClassOf NCIT_C227 @default.
- NCIT_C227 subClassOf NCIT_C28197 @default.
- NCIT_C227 subClassOf NCIT_C29756 @default.
- NCIT_C227 subClassOf NCIT_C78272 @default.