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- NCIT_C230 IAO_0000115 "The sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria." @default.
- NCIT_C230 NCIT_A6 NCIT_C61615 @default.
- NCIT_C230 NCIT_NHC0 "C230" @default.
- NCIT_C230 NCIT_P106 "Antibiotic" @default.
- NCIT_C230 NCIT_P106 "Organic Chemical" @default.
- NCIT_C230 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C230 NCIT_P108 "Amikacin Sulfate" @default.
- NCIT_C230 NCIT_P175 "177001" @default.
- NCIT_C230 NCIT_P207 "C0700949" @default.
- NCIT_C230 NCIT_P210 "39831-55-5" @default.
- NCIT_C230 NCIT_P319 "N6M33094FD" @default.
- NCIT_C230 NCIT_P322 "FDA" @default.
- NCIT_C230 NCIT_P329 "39145" @default.
- NCIT_C230 NCIT_P330 "39145" @default.
- NCIT_C230 NCIT_P350 "C22H43N5O13.2H2O4S" @default.
- NCIT_C230 NCIT_P366 "Amikacin" @default.
- NCIT_C230 NCIT_P368 "CHEBI:2638" @default.
- NCIT_C230 NCIT_P399 "39145" @default.
- NCIT_C230 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C230 referenceCount "3" @default.
- NCIT_C230 hasExactSynonym "AMIKACIN SULFATE" @default.
- NCIT_C230 hasExactSynonym "Amikacin Sulfate" @default.
- NCIT_C230 hasExactSynonym "Amikin" @default.
- NCIT_C230 inSubset NCIT_C176424 @default.
- NCIT_C230 inSubset NCIT_C63923 @default.
- NCIT_C230 type Class @default.
- NCIT_C230 isDefinedBy ncit.owl @default.
- NCIT_C230 label "Amikacin Sulfate" @default.
- NCIT_C230 subClassOf NCIT_C1908 @default.
- NCIT_C230 subClassOf NCIT_C1909 @default.
- NCIT_C230 subClassOf NCIT_C230 @default.
- NCIT_C230 subClassOf NCIT_C2363 @default.
- NCIT_C230 subClassOf NCIT_C254 @default.
- NCIT_C230 subClassOf NCIT_C258 @default.
- NCIT_C230 subClassOf NCIT_C784 @default.