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- NCIT_C2309 IAO_0000115 "A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an adjuvant in chemotherapy. Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells. When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity." @default.
- NCIT_C2309 NCIT_NHC0 "C2309" @default.
- NCIT_C2309 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2309 NCIT_P106 "Enzyme" @default.
- NCIT_C2309 NCIT_P108 "Glutaminase-Asparaginase" @default.
- NCIT_C2309 NCIT_P175 "215140" @default.
- NCIT_C2309 NCIT_P208 "CL448368" @default.
- NCIT_C2309 NCIT_P210 "39335-03-0" @default.
- NCIT_C2309 NCIT_P329 "39251" @default.
- NCIT_C2309 NCIT_P330 "39251" @default.
- NCIT_C2309 NCIT_P366 "Glutaminase-Asparaginase" @default.
- NCIT_C2309 NCIT_P399 "39251" @default.
- NCIT_C2309 normalizedInformationContent "100" @default.
- NCIT_C2309 referenceCount "1" @default.
- NCIT_C2309 hasExactSynonym "Glutaminase-Asparaginase" @default.
- NCIT_C2309 inSubset NCIT_C176424 @default.
- NCIT_C2309 type Class @default.
- NCIT_C2309 isDefinedBy ncit.owl @default.
- NCIT_C2309 label "Glutaminase-Asparaginase" @default.
- NCIT_C2309 subClassOf NCIT_C177280 @default.
- NCIT_C2309 subClassOf NCIT_C177430 @default.
- NCIT_C2309 subClassOf NCIT_C1908 @default.
- NCIT_C2309 subClassOf NCIT_C1909 @default.
- NCIT_C2309 subClassOf NCIT_C2309 @default.
- NCIT_C2309 subClassOf NCIT_C274 @default.
- NCIT_C2309 subClassOf NCIT_C29726 @default.
- NCIT_C2309 subClassOf NCIT_C307 @default.