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- NCIT_C2328 IAO_0000115 "The sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, cefotaxime sodium is more active against gram-negative bacteria and less active against gram-positive bacteria." @default.
- NCIT_C2328 NCIT_A6 NCIT_C354 @default.
- NCIT_C2328 NCIT_NHC0 "C2328" @default.
- NCIT_C2328 NCIT_P106 "Antibiotic" @default.
- NCIT_C2328 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2328 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2328 NCIT_P108 "Cefotaxime Sodium" @default.
- NCIT_C2328 NCIT_P207 "C0700445" @default.
- NCIT_C2328 NCIT_P210 "64485-93-4" @default.
- NCIT_C2328 NCIT_P319 "258J72S7TZ" @default.
- NCIT_C2328 NCIT_P322 "FDA" @default.
- NCIT_C2328 NCIT_P350 "C16H16N5O7S2.Na" @default.
- NCIT_C2328 NCIT_P366 "Cefotaxime_Sodium" @default.
- NCIT_C2328 NCIT_P368 "CHEBI:3498" @default.
- NCIT_C2328 normalizedInformationContent "100" @default.
- NCIT_C2328 referenceCount "1" @default.
- NCIT_C2328 hasExactSynonym "CEFOTAXIME SODIUM" @default.
- NCIT_C2328 hasExactSynonym "Cefotaxime Sodium" @default.
- NCIT_C2328 hasExactSynonym "Claforan" @default.
- NCIT_C2328 inSubset NCIT_C63923 @default.
- NCIT_C2328 type Class @default.
- NCIT_C2328 isDefinedBy ncit.owl @default.
- NCIT_C2328 label "Cefotaxime Sodium" @default.
- NCIT_C2328 subClassOf NCIT_C1908 @default.
- NCIT_C2328 subClassOf NCIT_C1909 @default.
- NCIT_C2328 subClassOf NCIT_C2328 @default.
- NCIT_C2328 subClassOf NCIT_C254 @default.
- NCIT_C2328 subClassOf NCIT_C258 @default.
- NCIT_C2328 subClassOf NCIT_C260 @default.
- NCIT_C2328 subClassOf NCIT_C357 @default.