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- NCIT_C2331 IAO_0000115 "A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed only by B lymphocytes and follicular dendritic cells, while over-expressed in B-lineage lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death." @default.
- NCIT_C2331 NCIT_NHC0 "C2331" @default.
- NCIT_C2331 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2331 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2331 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2331 NCIT_P108 "B43-PAP Immunotoxin" @default.
- NCIT_C2331 NCIT_P207 "C0796424" @default.
- NCIT_C2331 NCIT_P325 "A toxic substance linked to an antibody that attaches to tumor cells and kills them." @default.
- NCIT_C2331 NCIT_P329 "43266" @default.
- NCIT_C2331 NCIT_P330 "43266" @default.
- NCIT_C2331 NCIT_P366 "B43-PAP_Immunotoxin" @default.
- NCIT_C2331 NCIT_P399 "43266" @default.
- NCIT_C2331 normalizedInformationContent "100" @default.
- NCIT_C2331 referenceCount "1" @default.
- NCIT_C2331 hasExactSynonym "B43 Immunotoxin" @default.
- NCIT_C2331 hasExactSynonym "B43-PAP Immunotoxin" @default.
- NCIT_C2331 hasExactSynonym "B43-PAP immunotoxin" @default.
- NCIT_C2331 hasExactSynonym "B43-PAP" @default.
- NCIT_C2331 hasExactSynonym "B43-Pokeweed Antiviral Protein Immunotoxin" @default.
- NCIT_C2331 inSubset NCIT_C176424 @default.
- NCIT_C2331 type Class @default.
- NCIT_C2331 isDefinedBy ncit.owl @default.
- NCIT_C2331 label "B43-PAP Immunotoxin" @default.
- NCIT_C2331 subClassOf NCIT_C1512 @default.
- NCIT_C2331 subClassOf NCIT_C163758 @default.
- NCIT_C2331 subClassOf NCIT_C1908 @default.
- NCIT_C2331 subClassOf NCIT_C1909 @default.
- NCIT_C2331 subClassOf NCIT_C198634 @default.
- NCIT_C2331 subClassOf NCIT_C2330 @default.
- NCIT_C2331 subClassOf NCIT_C2331 @default.
- NCIT_C2331 subClassOf NCIT_C274 @default.
- NCIT_C2331 subClassOf NCIT_C307 @default.
- NCIT_C2331 subClassOf NCIT_C308 @default.
- NCIT_C2331 subClassOf NCIT_C575 @default.