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- NCIT_C2334 IAO_0000115 "An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to two deglycosylated ricin toxin A-chain (Di-dgA). This agent can be extracted from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This Di-dgA conjugated MoAb RFB4 delivers 7 fold more cytotoxicity than the single dgA immunotoxin against CD22-positive malignant cells." @default.
- NCIT_C2334 NCIT_NHC0 "C2334" @default.
- NCIT_C2334 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2334 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2334 NCIT_P108 "Di-dgA-RFB4 Immunotoxin" @default.
- NCIT_C2334 NCIT_P207 "C0677768" @default.
- NCIT_C2334 NCIT_P325 "An anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA)." @default.
- NCIT_C2334 NCIT_P329 "42825" @default.
- NCIT_C2334 NCIT_P330 "42825" @default.
- NCIT_C2334 NCIT_P366 "Di-dgA-RFB4_Immunotoxin" @default.
- NCIT_C2334 NCIT_P399 "42825" @default.
- NCIT_C2334 normalizedInformationContent "100" @default.
- NCIT_C2334 referenceCount "1" @default.
- NCIT_C2334 hasExactSynonym "Di-dgA-RFB4 Immunotoxin" @default.
- NCIT_C2334 hasExactSynonym "Di-dgA-RFB4 Monoclonal Antibody" @default.
- NCIT_C2334 hasExactSynonym "Monoclonal Antibody Di-dgA-RFB4" @default.
- NCIT_C2334 hasExactSynonym "di-dgA-RFB4" @default.
- NCIT_C2334 inSubset NCIT_C176424 @default.
- NCIT_C2334 type Class @default.
- NCIT_C2334 isDefinedBy ncit.owl @default.
- NCIT_C2334 label "Di-dgA-RFB4 Immunotoxin" @default.
- NCIT_C2334 subClassOf NCIT_C1512 @default.
- NCIT_C2334 subClassOf NCIT_C1908 @default.
- NCIT_C2334 subClassOf NCIT_C1909 @default.
- NCIT_C2334 subClassOf NCIT_C2002 @default.
- NCIT_C2334 subClassOf NCIT_C2334 @default.
- NCIT_C2334 subClassOf NCIT_C2359 @default.
- NCIT_C2334 subClassOf NCIT_C307 @default.
- NCIT_C2334 subClassOf NCIT_C308 @default.
- NCIT_C2334 subClassOf NCIT_C575 @default.