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- NCIT_C2337 IAO_0000115 "The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling." @default.
- NCIT_C2337 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2337 NCIT_NHC0 "C2337" @default.
- NCIT_C2337 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2337 NCIT_P108 "Sodium Butyrate" @default.
- NCIT_C2337 NCIT_P175 "174280" @default.
- NCIT_C2337 NCIT_P207 "C0142812" @default.
- NCIT_C2337 NCIT_P210 "156-54-7" @default.
- NCIT_C2337 NCIT_P319 "8RAS91C36W" @default.
- NCIT_C2337 NCIT_P322 "FDA" @default.
- NCIT_C2337 NCIT_P322 "GDC" @default.
- NCIT_C2337 NCIT_P329 "39601" @default.
- NCIT_C2337 NCIT_P330 "39601" @default.
- NCIT_C2337 NCIT_P350 "C4H7O2.Na" @default.
- NCIT_C2337 NCIT_P366 "Sodium_Butyrate" @default.
- NCIT_C2337 NCIT_P368 "CHEBI:64103" @default.
- NCIT_C2337 NCIT_P375 "Sodium Butyrate" @default.
- NCIT_C2337 NCIT_P399 "39601" @default.
- NCIT_C2337 normalizedInformationContent "100" @default.
- NCIT_C2337 referenceCount "1" @default.
- NCIT_C2337 hasExactSynonym "Butyrate sodium" @default.
- NCIT_C2337 hasExactSynonym "Butyrate" @default.
- NCIT_C2337 hasExactSynonym "Butyric Acid, Sodium Salt" @default.
- NCIT_C2337 hasExactSynonym "SODIUM BUTYRATE" @default.
- NCIT_C2337 hasExactSynonym "Sodium Butyrate" @default.
- NCIT_C2337 hasExactSynonym "Sodium butanoate" @default.
- NCIT_C2337 hasExactSynonym "Sodium butyrate" @default.
- NCIT_C2337 hasExactSynonym "butyric acid, sodium salt" @default.
- NCIT_C2337 hasExactSynonym "sodium butanoate" @default.
- NCIT_C2337 inSubset NCIT_C128784 @default.
- NCIT_C2337 inSubset NCIT_C157711 @default.
- NCIT_C2337 inSubset NCIT_C157712 @default.
- NCIT_C2337 inSubset NCIT_C176424 @default.
- NCIT_C2337 inSubset NCIT_C177537 @default.
- NCIT_C2337 inSubset NCIT_C63923 @default.
- NCIT_C2337 type Class @default.
- NCIT_C2337 isDefinedBy ncit.owl @default.
- NCIT_C2337 label "Sodium Butyrate" @default.
- NCIT_C2337 subClassOf NCIT_C163758 @default.
- NCIT_C2337 subClassOf NCIT_C1908 @default.
- NCIT_C2337 subClassOf NCIT_C1909 @default.
- NCIT_C2337 subClassOf NCIT_C1946 @default.
- NCIT_C2337 subClassOf NCIT_C2337 @default.
- NCIT_C2337 subClassOf NCIT_C274 @default.
- NCIT_C2337 subClassOf NCIT_C471 @default.