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- NCIT_C2374 IAO_0000115 "A chimeric fusion protein containing human transforming growth factor alpha (TGF-a) covalently linked to a truncated form of the bacterial toxin Pseudomonas exotoxin A, PE40, with potential antitumor activity. PE40 lacks the cell-binding domain, but retains domains II and III that are involved in membrane translocation and inhibition of protein synthesis in eukaryotic cells. TGF-a moiety of the TP40 immunotoxin binds to and activates epidermal growth factor receptor (EGFR), a tyrosine kinase receptor overexpressed on certain cancer cells. After internalization, the endotoxin moiety of the immunotoxin-receptor complex causes protein synthesis inhibition via modifying translation elongation factor 2 (EF-2), thereby impedes tumor cell growth and proliferation." @default.
- NCIT_C2374 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2374 NCIT_NHC0 "C2374" @default.
- NCIT_C2374 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2374 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2374 NCIT_P108 "TP40 Immunotoxin" @default.
- NCIT_C2374 NCIT_P207 "C0247342" @default.
- NCIT_C2374 NCIT_P322 "GDC" @default.
- NCIT_C2374 NCIT_P329 "41531" @default.
- NCIT_C2374 NCIT_P330 "41531" @default.
- NCIT_C2374 NCIT_P366 "TP40_Immunotoxin" @default.
- NCIT_C2374 NCIT_P375 "TP40 Immunotoxin" @default.
- NCIT_C2374 NCIT_P399 "41531" @default.
- NCIT_C2374 normalizedInformationContent "100" @default.
- NCIT_C2374 referenceCount "1" @default.
- NCIT_C2374 hasExactSynonym "TP40 Immunotoxin" @default.
- NCIT_C2374 hasExactSynonym "TP40" @default.
- NCIT_C2374 hasExactSynonym "Transforming Growth Factor-Alpha-Pseudomonas Exotoxin-40" @default.
- NCIT_C2374 inSubset NCIT_C128784 @default.
- NCIT_C2374 inSubset NCIT_C157711 @default.
- NCIT_C2374 inSubset NCIT_C157712 @default.
- NCIT_C2374 inSubset NCIT_C176424 @default.
- NCIT_C2374 inSubset NCIT_C177537 @default.
- NCIT_C2374 type Class @default.
- NCIT_C2374 isDefinedBy ncit.owl @default.
- NCIT_C2374 label "TP40 Immunotoxin" @default.
- NCIT_C2374 subClassOf NCIT_C1512 @default.
- NCIT_C2374 subClassOf NCIT_C1908 @default.
- NCIT_C2374 subClassOf NCIT_C1909 @default.
- NCIT_C2374 subClassOf NCIT_C2374 @default.
- NCIT_C2374 subClassOf NCIT_C307 @default.
- NCIT_C2374 subClassOf NCIT_C308 @default.
- NCIT_C2374 subClassOf NCIT_C575 @default.
- NCIT_C2374 subClassOf NCIT_C78532 @default.