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- NCIT_C2380 IAO_0000115 "An immunotoxin comprised of an anti-B4 (anti-CD19) murine monoclonal antibody linked to the modified plant-derived toxin blocked ricin. The antibody moiety of anti-B4 blocked ricin immunotoxin binds to B lymphocytes that express B4; after internalization of the immunotoxin by the B4-expressing B cell, the ricin moiety cleaves the N-glycosidic bond between the ribose and adenine base at position 4324 in the B lymphocyte 28S ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis, and cell death. Blocked ricin is ricin which has been chemically modified such that the lectin binding sites of the B chain (galactose-binding sites) have been blocked by covalent attachment of affinity ligands, leaving the ribosome-inactivating activity of the ricin A chain intact." @default.
- NCIT_C2380 NCIT_NHC0 "C2380" @default.
- NCIT_C2380 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2380 NCIT_P108 "Anti-B4 Blocked Ricin Immunotoxin" @default.
- NCIT_C2380 NCIT_P175 "639185" @default.
- NCIT_C2380 NCIT_P207 "C0763109" @default.
- NCIT_C2380 NCIT_P329 "41848" @default.
- NCIT_C2380 NCIT_P330 "41848" @default.
- NCIT_C2380 NCIT_P366 "Anti-B4_Blocked_Ricin_Immunotoxin" @default.
- NCIT_C2380 NCIT_P399 "41848" @default.
- NCIT_C2380 NCIT_R124 NCIT_C17710 @default.
- NCIT_C2380 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2380 NCIT_R124 NCIT_C18219 @default.
- NCIT_C2380 NCIT_R124 NCIT_C18966 @default.
- NCIT_C2380 NCIT_R124 NCIT_C19986 @default.
- NCIT_C2380 NCIT_R124 NCIT_C21049 @default.
- NCIT_C2380 NCIT_R124 NCIT_C28498 @default.
- NCIT_C2380 NCIT_R124 NCIT_C30022 @default.
- NCIT_C2380 NCIT_R124 NCIT_C40474 @default.
- NCIT_C2380 NCIT_R124 NCIT_C45554 @default.
- NCIT_C2380 NCIT_R125 NCIT_C17557 @default.
- NCIT_C2380 NCIT_R125 NCIT_C17710 @default.
- NCIT_C2380 NCIT_R125 NCIT_C17828 @default.
- NCIT_C2380 NCIT_R125 NCIT_C18966 @default.
- NCIT_C2380 NCIT_R125 NCIT_C20480 @default.
- NCIT_C2380 NCIT_R125 NCIT_C21049 @default.
- NCIT_C2380 NCIT_R125 NCIT_C21050 @default.
- NCIT_C2380 NCIT_R125 NCIT_C28498 @default.
- NCIT_C2380 NCIT_R125 NCIT_C29857 @default.
- NCIT_C2380 NCIT_R125 NCIT_C29860 @default.
- NCIT_C2380 NCIT_R125 NCIT_C30022 @default.
- NCIT_C2380 NCIT_R125 NCIT_C41515 @default.
- NCIT_C2380 NCIT_R146 NCIT_C17021 @default.
- NCIT_C2380 NCIT_R146 NCIT_C18515 @default.
- NCIT_C2380 NCIT_R146 NCIT_C20027 @default.
- NCIT_C2380 NCIT_R146 NCIT_C26231 @default.
- NCIT_C2380 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2380 NCIT_R146 NCIT_C38894 @default.
- NCIT_C2380 NCIT_R72 NCIT_C12219 @default.
- NCIT_C2380 NCIT_R72 NCIT_C12474 @default.
- NCIT_C2380 NCIT_R72 NCIT_C12508 @default.
- NCIT_C2380 NCIT_R72 NCIT_C12535 @default.
- NCIT_C2380 NCIT_R72 NCIT_C13269 @default.
- NCIT_C2380 NCIT_R72 NCIT_C13274 @default.
- NCIT_C2380 NCIT_R72 NCIT_C21599 @default.
- NCIT_C2380 NCIT_R72 NCIT_C32221 @default.
- NCIT_C2380 NCIT_R72 NCIT_C32725 @default.
- NCIT_C2380 NCIT_R72 NCIT_C33174 @default.
- NCIT_C2380 NCIT_R72 NCIT_C34070 @default.
- NCIT_C2380 normalizedInformationContent "100" @default.
- NCIT_C2380 referenceCount "1" @default.
- NCIT_C2380 hasExactSynonym "Anti B4-BR" @default.
- NCIT_C2380 hasExactSynonym "Anti B4bR" @default.
- NCIT_C2380 hasExactSynonym "Anti-B4 Blocked Ricin Immunotoxin" @default.
- NCIT_C2380 hasExactSynonym "Anti-B4 Blocked Ricin" @default.
- NCIT_C2380 hasExactSynonym "Anti-B4-bR" @default.
- NCIT_C2380 hasExactSynonym "Monoclonal Antibody Anti-B4 Blocked Ricin" @default.
- NCIT_C2380 inSubset NCIT_C176424 @default.
- NCIT_C2380 type Class @default.
- NCIT_C2380 isDefinedBy ncit.owl @default.
- NCIT_C2380 label "Anti-B4 Blocked Ricin Immunotoxin" @default.
- NCIT_C2380 subClassOf NCIT_C1512 @default.
- NCIT_C2380 subClassOf NCIT_C1908 @default.
- NCIT_C2380 subClassOf NCIT_C1909 @default.
- NCIT_C2380 subClassOf NCIT_C2359 @default.
- NCIT_C2380 subClassOf NCIT_C2380 @default.
- NCIT_C2380 subClassOf NCIT_C307 @default.
- NCIT_C2380 subClassOf NCIT_C308 @default.
- NCIT_C2380 subClassOf NCIT_C575 @default.
- NCIT_C2380 equivalentClass B1c374e26106fd1ed249f5ed7ee1ec664 @default.
- NCIT_C2380 equivalentClass Bf35ef2cff46e5809359814c277448865 @default.