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- NCIT_C239 IAO_0000115 "A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections." @default.
- NCIT_C239 NCIT_A5 NCIT_C47959 @default.
- NCIT_C239 NCIT_NHC0 "C239" @default.
- NCIT_C239 NCIT_P106 "Antibiotic" @default.
- NCIT_C239 NCIT_P106 "Organic Chemical" @default.
- NCIT_C239 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C239 NCIT_P108 "Ampicillin" @default.
- NCIT_C239 NCIT_P175 "528986" @default.
- NCIT_C239 NCIT_P207 "C0002680" @default.
- NCIT_C239 NCIT_P210 "69-53-4" @default.
- NCIT_C239 NCIT_P319 "7C782967RD" @default.
- NCIT_C239 NCIT_P322 "FDA" @default.
- NCIT_C239 NCIT_P350 "C16H19N3O4S" @default.
- NCIT_C239 NCIT_P366 "Ampicillin" @default.
- NCIT_C239 NCIT_P368 "CHEBI:28971" @default.
- NCIT_C239 normalizedInformationContent "100" @default.
- NCIT_C239 referenceCount "1" @default.
- NCIT_C239 hasExactSynonym "(2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid" @default.
- NCIT_C239 hasExactSynonym "AMPICILLIN" @default.
- NCIT_C239 hasExactSynonym "Ampicillin" @default.
- NCIT_C239 inSubset NCIT_C63923 @default.
- NCIT_C239 type Class @default.
- NCIT_C239 isDefinedBy ncit.owl @default.
- NCIT_C239 label "Ampicillin" @default.
- NCIT_C239 subClassOf NCIT_C1500 @default.
- NCIT_C239 subClassOf NCIT_C1908 @default.
- NCIT_C239 subClassOf NCIT_C1909 @default.
- NCIT_C239 subClassOf NCIT_C239 @default.
- NCIT_C239 subClassOf NCIT_C254 @default.
- NCIT_C239 subClassOf NCIT_C258 @default.
- NCIT_C239 subClassOf NCIT_C260 @default.