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- NCIT_C2408 IAO_0000115 "A topical lotion that contains the enzyme T4-bacteriophage endonuclease V encapsulated within liposomes. With topical liposomal delivery, the DNA repair enzyme T4-bacteriophage endonuclease V is transported into skin cells, where the enzyme enters cell nuclei and binds to and incises pyrimidine dimers, thereby catalyzing the first reaction step of the cellular excision repair pathway for removing DNA replication-inhibiting pyrimidine dimers produced within duplex DNA through exposure to ultraviolet (UV) irradiation. In vitro and in vivo studies indicate that T4N5 liposomes increases repair of DNA damage caused by UV irradiation. (NCI05)" @default.
- NCIT_C2408 NCIT_NHC0 "C2408" @default.
- NCIT_C2408 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2408 NCIT_P107 "T4N5 Liposomal Lotion" @default.
- NCIT_C2408 NCIT_P108 "T4N5 Liposomal Lotion" @default.
- NCIT_C2408 NCIT_P207 "C1710278" @default.
- NCIT_C2408 NCIT_P322 "CTRP" @default.
- NCIT_C2408 NCIT_P325 "A lotion being studied in the treatment of skin cancer and a skin condition called xeroderma pigmentosum. It has an enzyme contained in very tiny, fat-like particles. The enzyme repairs damage caused by ultraviolet radiation. T4N5 liposomal lotion is a type of DNA repair enzyme topical agent." @default.
- NCIT_C2408 NCIT_P329 "42482" @default.
- NCIT_C2408 NCIT_P330 "42482" @default.
- NCIT_C2408 NCIT_P366 "T4N5_Liposomal_Lotion" @default.
- NCIT_C2408 NCIT_P399 "42482" @default.
- NCIT_C2408 normalizedInformationContent "100" @default.
- NCIT_C2408 referenceCount "1" @default.
- NCIT_C2408 hasExactSynonym "Bacteriophage T4 Endonuclease V in Liposomal Lotion" @default.
- NCIT_C2408 hasExactSynonym "Dimericine" @default.
- NCIT_C2408 hasExactSynonym "Lotion, T4N5 Liposomal" @default.
- NCIT_C2408 hasExactSynonym "T4 Endonuclease V Liposomal Lotion" @default.
- NCIT_C2408 hasExactSynonym "T4N5 Liposomal Lotion" @default.
- NCIT_C2408 hasExactSynonym "T4N5 liposomal lotion" @default.
- NCIT_C2408 inSubset NCIT_C116977 @default.
- NCIT_C2408 inSubset NCIT_C116978 @default.
- NCIT_C2408 inSubset NCIT_C128784 @default.
- NCIT_C2408 inSubset NCIT_C176424 @default.
- NCIT_C2408 type Class @default.
- NCIT_C2408 isDefinedBy ncit.owl @default.
- NCIT_C2408 label "T4N5 Liposomal Lotion" @default.
- NCIT_C2408 subClassOf NCIT_C1908 @default.
- NCIT_C2408 subClassOf NCIT_C1909 @default.
- NCIT_C2408 subClassOf NCIT_C2252 @default.
- NCIT_C2408 subClassOf NCIT_C2253 @default.
- NCIT_C2408 subClassOf NCIT_C2408 @default.
- NCIT_C2408 subClassOf NCIT_C274 @default.