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- NCIT_C2415 IAO_0000115 "The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy." @default.
- NCIT_C2415 NCIT_NHC0 "C2415" @default.
- NCIT_C2415 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2415 NCIT_P108 "Oteracil Potassium" @default.
- NCIT_C2415 NCIT_P175 "28841" @default.
- NCIT_C2415 NCIT_P207 "C0393003" @default.
- NCIT_C2415 NCIT_P210 "2207-75-2" @default.
- NCIT_C2415 NCIT_P319 "4R7FFA00RX" @default.
- NCIT_C2415 NCIT_P322 "FDA" @default.
- NCIT_C2415 NCIT_P329 "42586" @default.
- NCIT_C2415 NCIT_P330 "42586" @default.
- NCIT_C2415 NCIT_P350 "C4H2N3O4.K" @default.
- NCIT_C2415 NCIT_P366 "Potassium_Oxonate" @default.
- NCIT_C2415 NCIT_P399 "42586" @default.
- NCIT_C2415 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2415 referenceCount "2" @default.
- NCIT_C2415 hasExactSynonym "OTERACIL POTASSIUM" @default.
- NCIT_C2415 hasExactSynonym "OXO" @default.
- NCIT_C2415 hasExactSynonym "Oteracil Potassium" @default.
- NCIT_C2415 hasExactSynonym "Oxonate Potassium" @default.
- NCIT_C2415 hasExactSynonym "Oxonate, potassium" @default.
- NCIT_C2415 hasExactSynonym "Oxonic Acid, Potassium Salt" @default.
- NCIT_C2415 hasExactSynonym "Potassium Oxonate" @default.
- NCIT_C2415 hasExactSynonym "Potassium oxonate" @default.
- NCIT_C2415 inSubset NCIT_C176424 @default.
- NCIT_C2415 inSubset NCIT_C63923 @default.
- NCIT_C2415 type Class @default.
- NCIT_C2415 isDefinedBy ncit.owl @default.
- NCIT_C2415 label "Oteracil Potassium" @default.
- NCIT_C2415 subClassOf NCIT_C1908 @default.
- NCIT_C2415 subClassOf NCIT_C1909 @default.
- NCIT_C2415 subClassOf NCIT_C2415 @default.
- NCIT_C2415 subClassOf NCIT_C471 @default.