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- NCIT_C2428 IAO_0000115 "A cell-based cancer vaccine with potential antineoplastic activity. PA-1-STK ovarian carcinoma vaccine is produced by transducing the ovarian cancer cell line, PA-1, with the herpes simplex thymidine kinase (HSV-tk) gene, resulting in a cell line, PA-1-STK, that permanently expresses the HSV tk gene. Upon transfection into malignant cells, this vaccine is capable of sensitizing tumor cells in response to an antiviral drug such as ganciclovir, which is readily phosphorylated by the TK enzyme to its active form. Administration of ganciclovir following PA-1 STK transfection results in enhanced cytotoxicity of the transfected tumor cells. Additionally, adjacent non-transfected cells are also killed by the activated antiviral drug, a phenomenon referred to as the bystander effect that occurs with this type of suicide-gene transfer technique." @default.
- NCIT_C2428 NCIT_NHC0 "C2428" @default.
- NCIT_C2428 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2428 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2428 NCIT_P108 "PA-1-STK Ovarian Carcinoma Vaccine" @default.
- NCIT_C2428 NCIT_P207 "C0393067" @default.
- NCIT_C2428 NCIT_P329 "42671" @default.
- NCIT_C2428 NCIT_P330 "42671" @default.
- NCIT_C2428 NCIT_P366 "PA-1-STK_Ovarian_Carcinoma_Vaccine" @default.
- NCIT_C2428 NCIT_P399 "42671" @default.
- NCIT_C2428 normalizedInformationContent "100" @default.
- NCIT_C2428 referenceCount "1" @default.
- NCIT_C2428 hasExactSynonym "PA-1-STK Ovarian Carcinoma Vaccine" @default.
- NCIT_C2428 inSubset NCIT_C128784 @default.
- NCIT_C2428 inSubset NCIT_C176424 @default.
- NCIT_C2428 type Class @default.
- NCIT_C2428 isDefinedBy ncit.owl @default.
- NCIT_C2428 label "PA-1-STK Ovarian Carcinoma Vaccine" @default.
- NCIT_C2428 subClassOf NCIT_C129820 @default.
- NCIT_C2428 subClassOf NCIT_C1663 @default.
- NCIT_C2428 subClassOf NCIT_C1908 @default.
- NCIT_C2428 subClassOf NCIT_C1909 @default.
- NCIT_C2428 subClassOf NCIT_C1962 @default.
- NCIT_C2428 subClassOf NCIT_C1983 @default.
- NCIT_C2428 subClassOf NCIT_C2341 @default.
- NCIT_C2428 subClassOf NCIT_C2428 @default.
- NCIT_C2428 subClassOf NCIT_C274 @default.
- NCIT_C2428 subClassOf NCIT_C307 @default.
- NCIT_C2428 subClassOf NCIT_C308 @default.
- NCIT_C2428 subClassOf NCIT_C923 @default.