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- NCIT_C2442 IAO_0000115 "A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. (NCI04)" @default.
- NCIT_C2442 NCIT_NHC0 "C2442" @default.
- NCIT_C2442 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2442 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2442 NCIT_P108 "Canarypox-hIL-12 Melanoma Vaccine" @default.
- NCIT_C2442 NCIT_P175 "689514" @default.
- NCIT_C2442 NCIT_P207 "C0677735" @default.
- NCIT_C2442 NCIT_P329 "42766" @default.
- NCIT_C2442 NCIT_P330 "42766" @default.
- NCIT_C2442 NCIT_P366 "Canarypox-hIL-12_Melanoma_Vaccine" @default.
- NCIT_C2442 NCIT_P399 "42766" @default.
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- NCIT_C2442 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2442 referenceCount "2" @default.
- NCIT_C2442 hasExactSynonym "ALVAC-hIL-12 melanoma vaccine" @default.
- NCIT_C2442 hasExactSynonym "ALVAC-hIL-12" @default.
- NCIT_C2442 hasExactSynonym "Canarypox-hIL-12 Melanoma Vaccine" @default.
- NCIT_C2442 inSubset NCIT_C128784 @default.
- NCIT_C2442 inSubset NCIT_C176424 @default.
- NCIT_C2442 type Class @default.
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- NCIT_C2442 label "Canarypox-hIL-12 Melanoma Vaccine" @default.
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