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- NCIT_C2461 IAO_0000115 "Ep-CAM (epithelial cell adhesion molecule) is a tumor-associated antigen, 40-kDa transmembrane glycoprotein, overexpressed in many solid tumors, including carcinomas of the lung, breast, ovary, colorectum, and squamous cell carcinoma of the head and neck. The role of Ep-CAM in carcinogenesis and malignant progression is unclear, but there is increasing evidence that it modulates cell-cell interactions and that its expression correlates with the rate of cell proliferation; a promoting role of Ep-CAM in tissue invasion and metastasis has been suggested. The limited expression of Ep-CAM in normal epithelial tissues and immunogenic MHC class I and II restricted epitopes identified on Ep-CAM, provide opportunities for developing effective multiepitope cancer vaccines targeting Ep-CAM. NR-LU-10 is an IgG2b murine monoclonal antibody against Ep-CAM." @default.
- NCIT_C2461 NCIT_A13 NCIT_C18421 @default.
- NCIT_C2461 NCIT_A9 NCIT_C20209 @default.
- NCIT_C2461 NCIT_NHC0 "C2461" @default.
- NCIT_C2461 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2461 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2461 NCIT_P108 "Ep-CAM" @default.
- NCIT_C2461 NCIT_P207 "C1704265" @default.
- NCIT_C2461 NCIT_P325 "A protein found on the surface of some cancers." @default.
- NCIT_C2461 NCIT_P366 "NR-LU-10_Antigen" @default.
- NCIT_C2461 normalizedInformationContent "100" @default.
- NCIT_C2461 referenceCount "1" @default.
- NCIT_C2461 hasExactSynonym "17-1A" @default.
- NCIT_C2461 hasExactSynonym "EGP-2" @default.
- NCIT_C2461 hasExactSynonym "Ep-CAM" @default.
- NCIT_C2461 hasExactSynonym "Epithelial Cell Adhesion Molecule" @default.
- NCIT_C2461 hasExactSynonym "GA733-2" @default.
- NCIT_C2461 hasExactSynonym "NR-LU-10 Antigen" @default.
- NCIT_C2461 hasExactSynonym "NR-LU-10 antigen" @default.
- NCIT_C2461 type Class @default.
- NCIT_C2461 isDefinedBy ncit.owl @default.
- NCIT_C2461 label "Ep-CAM" @default.
- NCIT_C2461 subClassOf NCIT_C1908 @default.
- NCIT_C2461 subClassOf NCIT_C1909 @default.
- NCIT_C2461 subClassOf NCIT_C2461 @default.
- NCIT_C2461 subClassOf NCIT_C268 @default.
- NCIT_C2461 subClassOf NCIT_C307 @default.
- NCIT_C2461 subClassOf NCIT_C912 @default.