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- NCIT_C2471 IAO_0000115 "A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Contusugene ladenovec induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04)" @default.
- NCIT_C2471 NCIT_A7 NCIT_C17387 @default.
- NCIT_C2471 NCIT_NHC0 "C2471" @default.
- NCIT_C2471 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2471 NCIT_P106 "Virus" @default.
- NCIT_C2471 NCIT_P107 "Contusugene Ladenovec" @default.
- NCIT_C2471 NCIT_P108 "Contusugene Ladenovec" @default.
- NCIT_C2471 NCIT_P175 "683550" @default.
- NCIT_C2471 NCIT_P207 "C1135129" @default.
- NCIT_C2471 NCIT_P210 "600735-73-7" @default.
- NCIT_C2471 NCIT_P319 "YPN57899MY" @default.
- NCIT_C2471 NCIT_P322 "CTRP" @default.
- NCIT_C2471 NCIT_P322 "FDA" @default.
- NCIT_C2471 NCIT_P329 "43016" @default.
- NCIT_C2471 NCIT_P330 "43016" @default.
- NCIT_C2471 NCIT_P366 "Ad5CMV-p53_Gene" @default.
- NCIT_C2471 NCIT_P399 "43016" @default.
- NCIT_C2471 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C2471 NCIT_R125 NCIT_C25868 @default.
- NCIT_C2471 NCIT_R125 NCIT_C28498 @default.
- NCIT_C2471 NCIT_R125 NCIT_C40715 @default.
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- NCIT_C2471 NCIT_R125 NCIT_C41543 @default.
- NCIT_C2471 NCIT_R125 NCIT_C51037 @default.
- NCIT_C2471 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C2471 referenceCount "5" @default.
- NCIT_C2471 hasExactSynonym "Ad-p53" @default.
- NCIT_C2471 hasExactSynonym "Ad5CMV p53 Gene" @default.
- NCIT_C2471 hasExactSynonym "Adeno-p53" @default.
- NCIT_C2471 hasExactSynonym "Adenovirus p53" @default.
- NCIT_C2471 hasExactSynonym "Advexin" @default.
- NCIT_C2471 hasExactSynonym "CONTUSUGENE LADENOVEC" @default.
- NCIT_C2471 hasExactSynonym "Contusugene Ladenovec" @default.
- NCIT_C2471 hasExactSynonym "INGN 201" @default.
- NCIT_C2471 hasExactSynonym "INGN-201" @default.
- NCIT_C2471 hasExactSynonym "INGN201" @default.
- NCIT_C2471 hasExactSynonym "RPR/INGN-201" @default.
- NCIT_C2471 hasExactSynonym "p53 Gene, Ad5CMV" @default.
- NCIT_C2471 inSubset NCIT_C116977 @default.
- NCIT_C2471 inSubset NCIT_C116978 @default.
- NCIT_C2471 inSubset NCIT_C128784 @default.
- NCIT_C2471 inSubset NCIT_C176424 @default.
- NCIT_C2471 inSubset NCIT_C63923 @default.
- NCIT_C2471 type Class @default.
- NCIT_C2471 isDefinedBy ncit.owl @default.
- NCIT_C2471 label "Contusugene Ladenovec" @default.
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- NCIT_C2471 subClassOf NCIT_C1909 @default.
- NCIT_C2471 subClassOf NCIT_C1962 @default.
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- NCIT_C2471 subClassOf NCIT_C274 @default.
- NCIT_C2471 subClassOf NCIT_C307 @default.
- NCIT_C2471 subClassOf NCIT_C61199 @default.